MEF2A

Gene Symbol MEF2A
Entrez Gene 4205
Alt Symbol ADCAD1, RSRFC4, RSRFC9, mef2
Species Human
Gene Type protein-coding
Description myocyte enhancer factor 2A
Other Description MADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A)|myocyte-specific enhancer factor 2A|serum response factor-like protein 1
Swissprots Q7Z6C9 Q02078 B4DFQ7 Q14223 Q96D14 O43814 Q59GX4 F6XG23 Q14224
Accessions AAB17195 AAB17196 EAX02249 EAX02250 EAX02251 EAX02252 Q02078 AB208985 BAD92222 AK291835 BAF84524 AK294207 BAG57518 AL831995 AM392739 CAL37617 AM393856 CAL38731 BC013437 AAH13437 BC053871 AAH53871 DA778137 EU446488 ABZ92017 N93079 X63381 CAA44979 X68503 CAA48516 X68504 X68505 CAA48517 Y16312 CAA76175 XM_005254914 XP_005254971 XM_005254915 XP_005254972 XM_005254916 XP_005254973 XM_011521571 XP_011519873 XM_011521572 XP_011519874 XM_011521573 XP_011519875 XM_011521574 XP_011519876 XM_011521575 XP_011519877 XM_011521576 XP_011519878 XM_011521577 XP_011519879 XM_011521578 XP_011519880 XM_011521579 XP_011519881 XM_011521580 XP_011519882 XM_011521581 XP_011519883 XM_011521582 XP_011519884 XM_011521583 XP_011519885 XM_011521584 XP_011519886 XM_011521585 XP_011519887 XM_011521586 XP_011519888 XM_011521587 XP_011519889 XM_011521588 XP_011519890 XM_011521589 XP_011519891 XM_011521590 XP_011519892 XR_931837 NM_001130926 NP_001124398 NM_001130927 NP_001124399 NM_001130928 NP_001124400 NM_001171894 NP_001165365 NM_005587 NP_005578
Function Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle- specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter. {ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15834131, ECO:0000269|PubMed:16371476, ECO:0000269|PubMed:16484498, ECO:0000269|PubMed:16563226, ECO:0000269|PubMed:21468593, ECO:0000269|PubMed:9858528}.
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00251, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:16563226}.
Tissue Specificity Isoform MEF2 and isoform MEFA are expressed only in skeletal and cardiac muscle and in the brain. Isoform RSRFC4 and isoform RSRFC9 are expressed in all tissues examined. {ECO:0000269|PubMed:1516833, ECO:0000269|PubMed:1748287}.
Top Pathways cGMP-PKG signaling pathway

MEF-2 CRISPR/Cas9 KO Plasmid (h) - sc-400484 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MEF-2 HDR Plasmid (h) - sc-400484-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MEF-2 Double Nickase Plasmid (h) - sc-400484-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MEF-2 Double Nickase Plasmid (h2) - sc-400484-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MEF-2 CRISPR Activation Plasmid (h) - sc-400484-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MEF-2 CRISPR Activation Plasmid (h2) - sc-400484-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MEF-2 Lentiviral Activation Particles (h) - sc-400484-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MEF-2 Lentiviral Activation Particles (h2) - sc-400484-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MEF-2A siRNA (h) - sc-35894 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MEF-2A shRNA Plasmid (h) - sc-35894-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MEF-2A shRNA (h) Lentiviral Particles - sc-35894-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MEF2A RNAi - H00004205-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU118321 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

MISSION® esiRNA - EHU064481 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN13186 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13186 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR07585 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr07585

MEF2A siRNA (Human) - CRH2859 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human MEF2A (NM_005587.2) - SHH340171 from Creative biogene

Category siRNA
Species Reactivities Human

Human MEF2A siRNA - orb263361 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

MEF2A shRNA Plasmid (Human) - CHH2859 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

MEF2A miRNA 3'UTR clone - MiUTR1H-06196 from Creative biogene

Species Reactivities Human

MEF2A miRNA 3'UTR clone - MiUTR1H-06197 from Creative biogene

Species Reactivities Human

MEF2A miRNA 3'UTR clone - MiUTR1H-06198 from Creative biogene

Species Reactivities Human

MEF2A miRNA 3'UTR clone - MiUTR1H-06199 from Creative biogene

Species Reactivities Human
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