| Gene Symbol |
CHST14
|
| Entrez Gene |
113189
|
| Alt Symbol |
ATCS, D4ST1, EDSMC1, HNK1ST
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14
|
| Other Description |
carbohydrate sulfotransferase 14|dermatan 4 sulfotransferase 1
|
| Swissprots |
Q8NCH0 Q6UXA0 Q96P94 Q6PJ31
|
| Accessions |
EAW92419 Q8NCH0 AB066595 BAB84097 AF282905 AAK69530 AF401222 AAK92532 AK074739 BAC11172 AY358446 AAQ88811 BC009883 BC023653 AAH23653 BC049214 AAH49214 BC053633 AAH53633 CR997569 HQ448147 ADQ32628 NM_130468 NP_569735
|
| Function |
Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of dermatan sulfate. Plays a pivotal role in the formation of 4-0-sulfated IdoA blocks in dermatan sulfate. Transfers sulfate to the C-4 hydroxyl of beta1,4-linked GalNAc that is substituted with an alpha-linked iduronic acid (IdoUA) at the C-3 hydroxyl. Transfers sulfate more efficiently to GalNAc residues in -IdoUA-GalNAc-IdoUA- than in -GlcUA-GalNAc-GlcUA-sequences. Has preference for partially desulfated dermatan sulfate. Addition of sulfate to GalNAc may occur immediately after epimerization of GlcUA to IdoUA. GlcUA to IdoUA. Appears to have an important role in the formation of the cerbellar neural network during postnatal brain development. {ECO:0000269|PubMed:19661164}.
|
| Subcellular Location |
Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Widely expressed. Expressed at high level in pituitary gland, placenta, uterus and thyroid. {ECO:0000269|PubMed:11470797}.
|
| Top Pathways |
Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
|