CHST14

Gene Symbol CHST14
Entrez Gene 113189
Alt Symbol ATCS, D4ST1, EDSMC1, HNK1ST
Species Human
Gene Type protein-coding
Description carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14
Other Description carbohydrate sulfotransferase 14|dermatan 4 sulfotransferase 1
Swissprots Q8NCH0 Q6UXA0 Q96P94 Q6PJ31
Accessions EAW92419 Q8NCH0 AB066595 BAB84097 AF282905 AAK69530 AF401222 AAK92532 AK074739 BAC11172 AY358446 AAQ88811 BC009883 BC023653 AAH23653 BC049214 AAH49214 BC053633 AAH53633 CR997569 HQ448147 ADQ32628 NM_130468 NP_569735
Function Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of dermatan sulfate. Plays a pivotal role in the formation of 4-0-sulfated IdoA blocks in dermatan sulfate. Transfers sulfate to the C-4 hydroxyl of beta1,4-linked GalNAc that is substituted with an alpha-linked iduronic acid (IdoUA) at the C-3 hydroxyl. Transfers sulfate more efficiently to GalNAc residues in -IdoUA-GalNAc-IdoUA- than in -GlcUA-GalNAc-GlcUA-sequences. Has preference for partially desulfated dermatan sulfate. Addition of sulfate to GalNAc may occur immediately after epimerization of GlcUA to IdoUA. GlcUA to IdoUA. Appears to have an important role in the formation of the cerbellar neural network during postnatal brain development. {ECO:0000269|PubMed:19661164}.
Subcellular Location Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Tissue Specificity Widely expressed. Expressed at high level in pituitary gland, placenta, uterus and thyroid. {ECO:0000269|PubMed:11470797}.
Top Pathways Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate

Human CHST14 full length protein - ab164997 from Abcam

Category Protein
Source Wheat germ
Species Human
ab164997 on a 12.5% SDS-PAGE stained with Coomassie Blue.

CHST14 Antibody Blocking Peptide - LS-E2836 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

CHST14 Antibody Blocking Peptide - LS-E17724 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

Recombinant Human CHST14 Protein - H00113189-P01 from Novus Biologicals

Category Protein
Prices $319.00
Sizes 2 µg
Source Wheat Germ
Species Human

CHST14-Antibody-Center-Blocking-peptide - BP13951c from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

CHST14 Blocking Peptide - 33R-7896 from Fitzgerald

Category Peptide
Prices $130.00
Sizes 100 µg

CHST14 - H00113189-P01 from Acris Antibodies

Category Protein
Prices $310.00
Sizes 2 µg
Species Human

CHST14 fusion protein - ag12014 from Proteintech Group

Category Protein
Source E. coli-derived, PGEX-4T
Species Human

CHST14 fusion protein - ag11802 from Proteintech Group

Category Protein
Source E. coli-derived, PET28a
Species Human

Recombinant Human CHST14, His-tagged - CHST14-100H from Creative Biomart

Category Protein
Source HEK293
Species Human

Recombinant Human Carbohydrate sulfotransferase 14(CHST14) - CSB-YP839851HU CSB-EP839851HU CSB-BP839851HU CSB-MP839851HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

CHST14 Peptide, Human - M34GP03149H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

CHST14 Recombinant Protein Antigen - NBP2-57389PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

CHST14 Recombinant Protein Antigen - NBP2-56997PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human
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