SLC27A4

Gene Symbol SLC27A4
Entrez Gene 10999
Alt Symbol ACSVL4, FATP4, IPS
Species Human
Gene Type protein-coding
Description solute carrier family 27 (fatty acid transporter), member 4
Other Description long-chain fatty acid transport protein 4
Swissprots A8K2F7 Q96G53 Q6P1M0 O95186
Accessions EAW87779 EAW87780 Q6P1M0 AA350218 AF055899 AAD11623 AI478495 AK000722 AK027504 BAG51333 AK074831 BAG52010 AK290222 BAF82911 AK314681 BC004268 AAH04268 BC009959 AAH09959 BC065003 AAH65003 H16504 NM_005094 NP_005085
Function Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Appears to be the principal fatty acid transporter in small intestinal enterocytes. Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (VLCFAs). Indirectly inhibits RPE65 via substrate competition and via production of VLCFA derivatives like lignoceroyl-CoA. Prevents light-induced degeneration of rods and cones (By similarity). {ECO:0000250}.
Subcellular Location Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000250}.
Tissue Specificity Expressed at highest levels in brain, testis, colon and kidney. Expressed at medium levels in heart and liver, small intestine and stomach. Expressed at low levels in peripheral leukocytes, bone marrow, skeletal muscle and aorta. Expressed in adipose tissue. {ECO:0000269|PubMed:9878842}.
Top Pathways PPAR signaling pathway, Fat digestion and absorption

Human SLC27A4 / FATP4 HEK293 Cell Lysate (WB positive control) - 13861-H07HL-300 from Sino Biological

Category Cell Lysate
Prices $195.00
Sizes 300 µg
Species Human

Human SLC27A4 Human Cells Transfected Lysate (positive control) (denatured) - orb179452 from Biorbyt

Category Cell Lysate
Prices $604.00
Sizes 300 μg
Species Human

Panoply™ Human SLC27A4 Knockdown Stable Cell Line - CSC-DC014468 from Creative biogene

Category Cell Line
Species Human

SLC27A4 KO Cell Lysate-HEK293T - CLKO-0775 from Creative biogene

Category Cell Lysate
Search more