SLC27A4
| Gene Symbol | SLC27A4 |
|---|---|
| Entrez Gene | 10999 |
| Alt Symbol | ACSVL4, FATP4, IPS |
| Species | Human |
| Gene Type | protein-coding |
| Description | solute carrier family 27 (fatty acid transporter), member 4 |
| Other Description | long-chain fatty acid transport protein 4 |
| Swissprots | A8K2F7 Q96G53 Q6P1M0 O95186 |
| Accessions | EAW87779 EAW87780 Q6P1M0 AA350218 AF055899 AAD11623 AI478495 AK000722 AK027504 BAG51333 AK074831 BAG52010 AK290222 BAF82911 AK314681 BC004268 AAH04268 BC009959 AAH09959 BC065003 AAH65003 H16504 NM_005094 NP_005085 |
| Function | Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Appears to be the principal fatty acid transporter in small intestinal enterocytes. Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (VLCFAs). Indirectly inhibits RPE65 via substrate competition and via production of VLCFA derivatives like lignoceroyl-CoA. Prevents light-induced degeneration of rods and cones (By similarity). {ECO:0000250}. |
| Subcellular Location | Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000250}. |
| Tissue Specificity | Expressed at highest levels in brain, testis, colon and kidney. Expressed at medium levels in heart and liver, small intestine and stomach. Expressed at low levels in peripheral leukocytes, bone marrow, skeletal muscle and aorta. Expressed in adipose tissue. {ECO:0000269|PubMed:9878842}. |
| Top Pathways | PPAR signaling pathway, Fat digestion and absorption |
ACSVL4 CRISPR/Cas9 KO Plasmid (h) - sc-402011 from Santa Cruz Biotechnology
|
||||||||
ACSVL4 HDR Plasmid (h) - sc-402011-HDR from Santa Cruz Biotechnology
|
||||||||
ACSVL4 Double Nickase Plasmid (h) - sc-402011-NIC from Santa Cruz Biotechnology
|
||||||||
ACSVL4 Double Nickase Plasmid (h2) - sc-402011-NIC-2 from Santa Cruz Biotechnology
|
||||||||
ACSVL4 CRISPR Activation Plasmid (h) - sc-402011-ACT from Santa Cruz Biotechnology
|
||||||||
ACSVL4 CRISPR Activation Plasmid (h2) - sc-402011-ACT-2 from Santa Cruz Biotechnology
|
||||||||
ACSVL4 Lentiviral Activation Particles (h) - sc-402011-LAC from Santa Cruz Biotechnology
|
||||||||
ACSVL4 Lentiviral Activation Particles (h2) - sc-402011-LAC-2 from Santa Cruz Biotechnology
|
||||||||
ACSVL4 siRNA (h) - sc-37094 from Santa Cruz Biotechnology
|
||||||||
ACSVL4 shRNA Plasmid (h) - sc-37094-SH from Santa Cruz Biotechnology
|
||||||||
ACSVL4 shRNA (h) Lentiviral Particles - sc-37094-V from Santa Cruz Biotechnology
|
||||||||
FATP4/SLC27A4 RNAi - H00010999-R01 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU069001 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN19534 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19534 from Sigma-Aldrich
|
||||||||
MISSION® 3′UTR Lenti GoClone™ - HUTR06196 from Sigma-Aldrich
|
||||||||
SLC27A4 siRNA (Human) - CRH7511 from Cohesion Biosciences
|
||||||||
SLC27A4 - MBS8232376 from MyBioSource
|
||||||||
shRNA set against Human SLC27A4 (NM_005094.3) - SHH410076 from Creative biogene
|
||||||||
Human SLC27A4 siRNA - orb268013 from Biorbyt
|
||||||||
SLC27A4 shRNA Plasmid (Human) - CHH7511 from Cohesion Biosciences
|
||||||||
SLC27A4 miRNA 3'UTR clone - MiUTR3H-06630 from Creative biogene
|