NBN

Gene Symbol	NBN
Entrez Gene	4683
Alt Symbol	AT-V1, AT-V2, ATV, NBS, NBS1, P95
Species	Human
Gene Type	protein-coding
Description	nibrin
Other Description	Nijmegen breakage syndrome 1 (nibrin)|cell cycle regulatory protein p95|p95 protein of the MRE11/RAD50 complex
Swissprots	Q53FM6 B2RNC5 B2R626 Q7LDM2 Q32NF7 O60934 Q63HR6 O60672
Accessions	AAC62232 AAS59158 AEX07903 AGW81285 AGW81286 AGW81287 AGW81288 AGW81289 AGW81290 AGW81291 BAA28616 CAI45369 EAW91660 EAW91661 O60934 AF051334 AAC39732 AF058696 AAC39752 AK001017 AK223256 BAD96976 AK289848 BAF82537 AK312410 BAG35323 BC005293 BC016762 AAH16762 BC040519 BC071590 BC108650 AAI08651 BC136802 AAI36803 BC136803 AAI36804 BC143065 AAI43066 BC143066 AAI43067 BC144413 BC146797 AAI46798 BX640816 CAH56160 DA634817 XM_005250923 XP_005250980 XM_011517044 XP_011515346 XM_011517045 XP_011515347 XM_011517046 XP_011515348 XR_928335 NM_001024688 NP_001019859 NM_002485 NP_002476
Function	Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of
Subcellular Location	Nucleus {ECO:0000250}. Nucleus, PML body {ECO:0000269|PubMed:12470659, ECO:0000269|PubMed:15916964}. Chromosome, telomere {ECO:0000250}. Note=Localizes to discrete nuclear foci after treatment with genotoxic agents. {ECO:0000250}.
Tissue Specificity	Ubiquitous. Expressed at high levels in testis.
Top Pathways	Homologous recombination

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human p95 NBS1 (unmodified ) peptide - ab12437 from Abcam Category Peptide

Human p95 NBS1 peptide - ab24289 from Abcam Category Peptide

Human p95 NBS1 protein fragment - ab158956 from Abcam Category Protein Source Wheat germ Species Human

NBN / Nibrin Antibody Blocking Peptide - LS-E1209 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NBN / Nibrin Antibody Blocking Peptide - LS-E31271 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

NBN / Nibrin Antibody Blocking Peptide - LS-E31272 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Nbs1 Blocking Peptide - NBP1-06705PEP from Novus Biologicals Category Peptide Prices $69.00 Sizes 50 µg Species Human

Nbs1 Blocking Peptide - NBP1-06609PEP from Novus Biologicals Category Peptide Prices $69.00 Sizes 50 µg Species Human

Recombinant Human Nbs1 Protein - H00004683-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

NBN-Antibody-C-term-Blocking-peptide - BP11776b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

NBN peptide - orb217649 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human

NBN peptide - orb219142 from Biorbyt Category Peptide Prices $357.00, $723.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

Nibrin (phospho-Ser343) Blocking Peptide - abx062173 from Abbexa Category Peptide Species Human, Mouse, Rat

Nibrin Blocking Peptide - abx062980 from Abbexa Category Peptide Species Human

Nibrin - H00004683-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

Nibrin - H00004683-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Nibrin - H00004683-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Nibrin (N-term) Control Peptide - AP55424CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

Nibrin (C-term) Control Peptide - AP55425CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

Nibrin (NBN), Human - 20-8555 from ARP American Research Products Category Protein Prices $505.00 Sizes 50 µg Source E.coli Species Human

Nibrin (NBN), Human - 20-8556 from ARP American Research Products Category Protein Prices $505.00 Sizes 50 µg Source E.coli Species Human

NIBRIN Peptide - 6839P from ProSci Category Peptide Species Human

NIBRIN Peptide - 6841P from ProSci Category Peptide Species Human

NBN fusion protein - ag19320 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

NBN fusion protein - ag17820 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

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