NBN

Gene Symbol	NBN
Entrez Gene	4683
Alt Symbol	AT-V1, AT-V2, ATV, NBS, NBS1, P95
Species	Human
Gene Type	protein-coding
Description	nibrin
Other Description	Nijmegen breakage syndrome 1 (nibrin)|cell cycle regulatory protein p95|p95 protein of the MRE11/RAD50 complex
Swissprots	Q53FM6 B2RNC5 B2R626 Q7LDM2 Q32NF7 O60934 Q63HR6 O60672
Accessions	AAC62232 AAS59158 AEX07903 AGW81285 AGW81286 AGW81287 AGW81288 AGW81289 AGW81290 AGW81291 BAA28616 CAI45369 EAW91660 EAW91661 O60934 AF051334 AAC39732 AF058696 AAC39752 AK001017 AK223256 BAD96976 AK289848 BAF82537 AK312410 BAG35323 BC005293 BC016762 AAH16762 BC040519 BC071590 BC108650 AAI08651 BC136802 AAI36803 BC136803 AAI36804 BC143065 AAI43066 BC143066 AAI43067 BC144413 BC146797 AAI46798 BX640816 CAH56160 DA634817 XM_005250923 XP_005250980 XM_011517044 XP_011515346 XM_011517045 XP_011515347 XM_011517046 XP_011515348 XR_928335 NM_001024688 NP_001019859 NM_002485 NP_002476
Function	Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of
Subcellular Location	Nucleus {ECO:0000250}. Nucleus, PML body {ECO:0000269|PubMed:12470659, ECO:0000269|PubMed:15916964}. Chromosome, telomere {ECO:0000250}. Note=Localizes to discrete nuclear foci after treatment with genotoxic agents. {ECO:0000250}.
Tissue Specificity	Ubiquitous. Expressed at high levels in testis.
Top Pathways	Homologous recombination

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Nibrin CRISPR/Cas9 KO Plasmid (h) - sc-401723 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Nibrin HDR Plasmid (h) - sc-401723-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Nibrin Double Nickase Plasmid (h) - sc-401723-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Nibrin Double Nickase Plasmid (h2) - sc-401723-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Nibrin CRISPR Activation Plasmid (h) - sc-401723-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Nibrin CRISPR Activation Plasmid (h2) - sc-401723-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Nibrin Lentiviral Activation Particles (h) - sc-401723-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Nibrin Lentiviral Activation Particles (h2) - sc-401723-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Nibrin siRNA (h) - sc-36061 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Nibrin shRNA Plasmid (h) - sc-36061-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Nibrin shRNA (h) Lentiviral Particles - sc-36061-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Nbs1 RNAi - H00004683-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU039471 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN2089 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2089 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR11162 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr11162

NBN siRNA (Human) - CRH3099 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

Nbs1 RNAi - H00004683-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

shRNA set against Human Nbn (NM_002485.4) - SHH349660 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human NBN(NM_002485.4) - SHH217267 from Creative biogene Category siRNA Species Reactivities Human

Human NBN siRNA - orb263601 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

NBN shRNA Plasmid (Human) - CHH3099 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

NBN miRNA 3'UTR clone - MiUTR1H-06656 from Creative biogene Species Reactivities Human

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