Gene Symbol | SS18 |
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Entrez Gene | 6760 |
Alt Symbol | SSXT, SYT |
Species | Human |
Gene Type | protein-coding |
Description | synovial sarcoma translocation, chromosome 18 |
Other Description | protein SSXT|synovial sarcoma translocated to X chromosome protein|synovial sarcoma, translocated to X chromosome |
Swissprots | Q15532 B0YJ95 Q4VAX1 Q9BXC6 |
Accessions | ACA06073 EAX01209 EAX01210 EAX01211 EAX01212 EAX01213 Q15532 AF161377 AAF28937 AF244972 AAM00188 AF343880 AAK21314 AK289510 BAF82199 AK296949 BAG59495 AK299082 BAG61146 AK301504 BAG63015 AK304305 BAG65158 AK307923 AK316302 BAH14673 AK316338 BAH14709 AU279615 AW081610 BC096221 AAH96221 BC096222 AAH96222 BC096223 AAH96223 BC096224 AAH96224 CR542088 CAG46885 CR542103 CAG46900 DC378335 EU832762 ACE87773 GQ129305 ACT64439 X79201 CAA55792 XM_005258334 XP_005258391 XM_006722527 XP_006722590 XM_011526145 XP_011524447 XM_011526146 XP_011524448 XM_011526147 XP_011524449 XM_011526148 XP_011524450 XM_011526149 XP_011524451 XM_011526150 XP_011524452 XM_011526151 XP_011524453 XM_011526152 XP_011524454 NM_001007559 NP_001007560 NM_001308201 NP_001295130 NM_005637 NP_005628 |
Function | Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation. {ECO:0000269|PubMed:15919756}. |
Subcellular Location | Nucleus {ECO:0000305}. |
Tissue Specificity | Fairly ubiquitously expressed. Expressed in synovial sarcomas and in other human cell lines. The fusion genes SSXT-SSX1 and SSXT-SSX2 are expressed only in synovial sarcomas. |
Top Pathways | Transcriptional misregulation in cancer |
SYT CRISPR/Cas9 KO Plasmid (h) - sc-401575 from Santa Cruz Biotechnology
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SYT HDR Plasmid (h) - sc-401575-HDR from Santa Cruz Biotechnology
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SYT Double Nickase Plasmid (h) - sc-401575-NIC from Santa Cruz Biotechnology
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SYT Double Nickase Plasmid (h2) - sc-401575-NIC-2 from Santa Cruz Biotechnology
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SYT CRISPR Activation Plasmid (h) - sc-401575-ACT from Santa Cruz Biotechnology
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SYT CRISPR Activation Plasmid (h2) - sc-401575-ACT-2 from Santa Cruz Biotechnology
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SYT Lentiviral Activation Particles (h) - sc-401575-LAC from Santa Cruz Biotechnology
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SYT Lentiviral Activation Particles (h2) - sc-401575-LAC-2 from Santa Cruz Biotechnology
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SYT siRNA (h) - sc-38449 from Santa Cruz Biotechnology
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SYT shRNA Plasmid (h) - sc-38449-SH from Santa Cruz Biotechnology
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SYT shRNA (h) Lentiviral Particles - sc-38449-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU071701 from Sigma-Aldrich
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MISSION® esiRNA - EHU089611 from Sigma-Aldrich
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MISSION® esiRNA - EHU104331 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20611 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20611 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR11035 from Sigma-Aldrich
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SS18 siRNA (Human) - CRH4623 from Cohesion Biosciences
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SS18 - MBS8233442 from MyBioSource
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shRNA set against Human SS18 (NM_005637.2) - SHH418308 from Creative biogene
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shRNA set against Human SS18(NM_001007559.1) - SHL035542 from Creative biogene
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shRNA set against Human SS18(NM_005637.2) - SHL035686 from Creative biogene
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Human SS18 siRNA - orb265125 from Biorbyt
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SS18 shRNA Plasmid (Human) - CHH4623 from Cohesion Biosciences
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SS18 miRNA 3'UTR clone - MiUTR1H-09920 from Creative biogene
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