| Gene Symbol | SOAT1 |
|---|---|
| Entrez Gene | 6646 |
| Alt Symbol | ACACT, ACAT, ACAT-1, ACAT1, SOAT, STAT |
| Species | Human |
| Gene Type | protein-coding |
| Description | sterol O-acyltransferase 1 |
| Other Description | acyl-coenzyme A:cholesterol acyltransferase 1|sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1 |
| Swissprots | Q5T0X4 B4DU95 A9Z1V7 P35610 Q8N1E4 A8K3P4 A6NC40 |
| Accessions | EAW91043 EAW91044 P35610 AK026611 AK290659 BAF83348 AK294047 BAG57399 AK300551 BAG62257 AK310920 AK316401 BAH14772 AL833625 BC028940 AAH28940 BQ182606 DC344271 DQ891807 ABM82733 DQ894991 ABM85917 L21934 AAC37532 XM_011509911 XP_011508213 XM_011509912 XP_011508214 NM_001252511 NP_001239440 NM_001252512 NP_001239441 NM_003101 NP_003092 NR_045530 |
| Function | Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:16154994}; Multi-pass membrane protein {ECO:0000269|PubMed:16154994}. |
| Top Pathways | Steroid biosynthesis |