SOAT1

Gene Symbol SOAT1
Entrez Gene 6646
Alt Symbol ACACT, ACAT, ACAT-1, ACAT1, SOAT, STAT
Species Human
Gene Type protein-coding
Description sterol O-acyltransferase 1
Other Description acyl-coenzyme A:cholesterol acyltransferase 1|sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1
Swissprots Q5T0X4 B4DU95 A9Z1V7 P35610 Q8N1E4 A8K3P4 A6NC40
Accessions EAW91043 EAW91044 P35610 AK026611 AK290659 BAF83348 AK294047 BAG57399 AK300551 BAG62257 AK310920 AK316401 BAH14772 AL833625 BC028940 AAH28940 BQ182606 DC344271 DQ891807 ABM82733 DQ894991 ABM85917 L21934 AAC37532 XM_011509911 XP_011508213 XM_011509912 XP_011508214 NM_001252511 NP_001239440 NM_001252512 NP_001239441 NM_003101 NP_003092 NR_045530
Function Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:16154994}; Multi-pass membrane protein {ECO:0000269|PubMed:16154994}.
Top Pathways Steroid biosynthesis

SOAT1 (ACAT-1) - sc-69836 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SOAT1 (ACAT-1): sc-69836. Western blot analysis of SOAT1 expression in THP-1 (A) and PMA-treated THP-1 (B) whole cell lysates.

SOAT1 (C-20) - sc-21029 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SOAT1 (C-20): sc-21029. Immunoperoxidase staining of formalin fixed, paraffin-embedded human upper stomach tissue showing cytoplasmic and weak nuclear staining of glandular cells.

SOAT1 (D-1) - sc-137013 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SOAT1 (D-1): sc-137013. Western blot analysis of SOAT1 expression in non-transfected 293T: sc-117752 (A), human SOAT1 transfected 293T: sc-113987 (B) and THP-1 (C) whole cell lysates.

SOAT1 (H-125) - sc-20951 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
SOAT1 (H-125): sc-20951. Immunoperoxidase staining of formalin fixed, paraffin-embedded human adrenal gland tissue showing cytoplasmic staining of cortical cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

SOAT1 (A-11) - sc-136959 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SOAT1 (A-11): sc-136959. Western blot analysis of SOAT1 expression in non-transfected: sc-117752 (A) and human SOAT1 transfected: sc-113987 (B) 293T whole cell lysates.

SOAT1 (N-20) - sc-21028 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SOAT1 (N-20): sc-21028. Western blot analysis of SOAT1 expression in Ramos (A) and Jurkat (B) whole cell lysates.

SOAT1 (S-20) - sc-21030 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SOAT1 (S-20): sc-21030. Western blot analysis of SOAT1 expression in THP-1 whole cell lysate.

Anti-SOAT 1 antibody - ab72229 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SOAT 1 antibody (ab72229) at 1 µg/mlLane 1 : Spleen (Mouse) Tissue Lysate Lane 2 : Ramos (Human Burkitt's lymphoma cell line) Whole Cell Lysate Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under non-reducing conditions.

Anti-SOAT 1 antibody - ab93477 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SOAT 1 antibody (ab93477) at 1/2000 dilutionLane 1 : Rat liver lysate at 65 µgLane 2 : Jurkat cell lysate at 28 µgLane 3 : SGC cell lysate at 33 µg

Anti-SOAT 1 antibody - ab39327 from Abcam

Prices $379.00
Sizes 300 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SOAT 1 antibody (ab39327)Lane 1 : Rat Liver (30µg)Lane 2 : HepG2 cell lysate (30µg)

Anti-SOAT 1 antibody [AT2.H11] - ab21475 from Abcam

Prices $390.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone AT2.H11
Ab21475 staining Human normal placenta. Staining is localized to cytoplasmic compartment.Left panel: with primary antibody at 1 ug/ml. Right panel: isotype control.Sections were stained using an automated system DAKO Autostainer Plus , at room temperature. Sections were rehydrated and antigen retrieved with the Dako 3-in-1 AR buffers citrate pH 6.0 in a DAKO PT Link. Slides were peroxidase blocked in 3% H2O2 in methanol for 10 minutes. They were then blocked with Dako Protein block for 10 minutes (containing casein 0.25% in PBS) then incubated with primary antibody for 20 minutes and detected with Dako Envision Flex amplification kit for 30 minutes. Colorimetric detection was completed with Diaminobenzidine for 5 minutes. Slides were counterstained with Haematoxylin and coverslipped under DePeX. Please note that for manual staining we recommend to optimize the primary antibody concentration and incubation time (overnight incubation), and amplification may be required.

Anti-SOAT 1 antibody [EP1376Y] - ab53008 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP1376Y
Anti-SOAT 1 antibody [EP1376Y] (ab53008) at 1/10000 dilution + U937 cell lysate at 10 µgSecondarygoat anti-rabbit HRP labelled at 1/2000 dilution

Anti-SOAT1 Antibody (aa6-23) IHC-plus™ - LS-B1586 from LifeSpan Bioscience

Prices $395.00
Sizes 1 ea
Host Rabbit
Clonality Polyclonal
Anti-SOAT1 / STAT antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1586 concentration 5 ug/ml.

Anti-SOAT1 / STAT Antibody (N-Terminus) - LS-C79260 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-SOAT1 Antibody (N-Terminus) - LS-C79263 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SOAT1 Antibody - LS-C190061 from LifeSpan Bioscience

Prices $515.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SOAT1 Antibody (aa251-300) - LS-C117172 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SOAT1 / STAT antibody LS-C117172 Western blot of HeLa lysate.

Anti-SOAT1 Antibody - LS-C334633 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of 293T cell line, using SOAT1 antibody.

ACAT Antibody - NB400-141 from Novus Biologicals

Prices $99.00, $279.00
Sizes 25 µl, 100 µl
Host Rabbit
Clonality Polyclonal

ACAT Antibody - NBP2-32052 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: ACAT Antibody [NBP2-32052] - Immunofluorescent staining of human cell line A-431 shows localization to endoplasmic reticulum.

ACAT Antibody - NBP1-80547 from Novus Biologicals

Prices $369.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western Blot: ACAT Antibody [NBP1-80547] - Hela cell lysate, concentration 0.2-1 ug/ml.

ACAT Antibody - H00006646-D01 from Novus Biologicals

Prices $399.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

SOAT1 Polyclonal Antibody - bs-7544R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin embedded rat testis tissue labeled with Anti-SOAT1 Polyclonal Antibody, Unconjugated(bs-7544R) 1:400 followed by conjugation to the secondary antibody and DAB staining

Anti-SOAT1 antibody produced in rabbit - HPA047171 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-SOAT1: <B>Cat. No. HPA047171</B>: Immunohistochemical staining of Human adrenal gland shows strong cytoplasmic positivity in glandular cells.

Anti-SOAT1 antibody produced in rabbit - SAB2106708 from Sigma-Aldrich

Prices $341.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-SOAT1: <B>Cat. No. SAB2106708</B>: Western blot analysis of SOAT1 with SOAT1 (sterol O-acyltransferase 1) antibody against the middle region of SOAT1 (50 μg) antibody at 1.0 μg/mL.
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