Gene Symbol | SOAT1 |
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Entrez Gene | 6646 |
Alt Symbol | ACACT, ACAT, ACAT-1, ACAT1, SOAT, STAT |
Species | Human |
Gene Type | protein-coding |
Description | sterol O-acyltransferase 1 |
Other Description | acyl-coenzyme A:cholesterol acyltransferase 1|sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1 |
Swissprots | Q5T0X4 B4DU95 A9Z1V7 P35610 Q8N1E4 A8K3P4 A6NC40 |
Accessions | EAW91043 EAW91044 P35610 AK026611 AK290659 BAF83348 AK294047 BAG57399 AK300551 BAG62257 AK310920 AK316401 BAH14772 AL833625 BC028940 AAH28940 BQ182606 DC344271 DQ891807 ABM82733 DQ894991 ABM85917 L21934 AAC37532 XM_011509911 XP_011508213 XM_011509912 XP_011508214 NM_001252511 NP_001239440 NM_001252512 NP_001239441 NM_003101 NP_003092 NR_045530 |
Function | Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:16154994}; Multi-pass membrane protein {ECO:0000269|PubMed:16154994}. |
Top Pathways | Steroid biosynthesis |
SOAT1 CRISPR/Cas9 KO Plasmid (h) - sc-417623 from Santa Cruz Biotechnology
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SOAT1 HDR Plasmid (h) - sc-417623-HDR from Santa Cruz Biotechnology
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SOAT1 Double Nickase Plasmid (h) - sc-417623-NIC from Santa Cruz Biotechnology
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SOAT1 Double Nickase Plasmid (h2) - sc-417623-NIC-2 from Santa Cruz Biotechnology
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SOAT1 CRISPR Activation Plasmid (h) - sc-417623-ACT from Santa Cruz Biotechnology
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SOAT1 CRISPR Activation Plasmid (h2) - sc-417623-ACT-2 from Santa Cruz Biotechnology
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SOAT1 Lentiviral Activation Particles (h) - sc-417623-LAC from Santa Cruz Biotechnology
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SOAT1 Lentiviral Activation Particles (h2) - sc-417623-LAC-2 from Santa Cruz Biotechnology
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SOAT1 siRNA (h) - sc-29624 from Santa Cruz Biotechnology
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SOAT1 shRNA Plasmid (h) - sc-29624-SH from Santa Cruz Biotechnology
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SOAT1 shRNA (h) Lentiviral Particles - sc-29624-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU000571 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20317 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20317 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10215 from Sigma-Aldrich
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SOAT1 siRNA (Human) - CRH4526 from Cohesion Biosciences
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SOAT1 - MBS8203198 from MyBioSource
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shRNA set against Human SOAT1 (NM_003101.5) - SHH414904 from Creative biogene
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SOAT1 shRNA Plasmid (Human) - CHH4526 from Cohesion Biosciences
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SOAT1 miRNA 3'UTR clone - MiUTR3H-00047 from Creative biogene
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