SERPINA1

Gene Symbol	SERPINA1
Entrez Gene	5265
Alt Symbol	A1A, A1AT, AAT, PI, PI1, PRO2275, alpha1AT
Species	Human
Gene Type	protein-coding
Description	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
Other Description	alpha-1 protease inhibitor\|alpha-1-antiproteinase\|alpha-1-antitrypsin\|alpha-1-antitrypsin null\|protease inhibitor 1 (anti-elastase), alpha-1-antitrypsin\|serine (or cysteine) proteinase inhibitor, clade A, member 1\|serpin A1
Swissprots	Q9UCM3 Q96BF9 A6PX14 B2RDQ8 Q9P1P0 Q5U0M1 P01009 Q86U18 Q7M4R2 Q53XB8 Q86U19 Q96ES1 Q13672 Q9UCE6 Q0PVP5
Accessions	AAA51547 AAB59369 AAB59370 AAB59371 AAB59495 AAF15128 AAP13998 ABA41642 ABC62080 ABR29795 ABS30840 ABS30841 ACB47283 ACR55079 CAJ15161 EAW81570 EAW81571 EAW81572 EAW81573 EAW81574 EAW81575 EAW81576 P01009 AA317159 AF119873 AAF69627 AK026174 AK315637 BAG38005 BC011991 AAH11991 BC015642 AAH15642 BC070163 BG483969 BM844817 BM923322 BP296710 BP300943 BP301274 BT019455 AAV38262 BX161449 CAD61914 BX247968 CAD62306 BX248002 CAD62334 BX248257 CAD62585 BX477352 CD685665 DA427262 DA428299 DA433050 DA433058 DA672472 DA675981 DA966896 DQ682455 ABG73380 FJ830375 ACO55054 GU727620 ADU87622 HQ448245 ADQ32725 K01396 AAB59375 M11465 AAA51546 M26123 AAA51545 V00496 CAA23755 X01683 CAA25838 X02920 CAA26677 X05826 CAA29267 X05827 X17122 CAA34982 NM_000295 NP_000286 NM_001002235 NP_001002235 NM_001002236 NP_001002236 NM_001127700 NP_001121172 NM_001127701 NP_001121173 NM_001127702 NP_001121174 NM_001127703 NP_001121175 NM_001127704 NP_001121176 NM_001127705 NP_001121177 NM_001127706 NP_001121178 NM_001127707 NP_001121179
Function	Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.
Subcellular Location	Secreted. Endoplasmic reticulum. Note=The S and Z allele are not secreted effectively and accumulate intracellularly in the endoplasmic reticulum.
Tissue Specificity	Ubiquitous. Expressed in leukocytes and plasma. {ECO:0000269\|PubMed:23826168}.
Top Pathways	Complement and coagulation cascades

alpha 1 Antitrypsin (SERPINA1) Human ELISA Kit - ab108799 from Abcam

Category	ELISA Kit
Prices	$489.00
Sizes	1 x 96 tests
Sensitivity	= 0.35 ng/ml
Range	0.391 ng/ml - 100 ng/ml

Representative Standard Curve using ab108799

alpha 1 Antitrypsin (SERPINA1) Human ELISA Kit - ab108798 from Abcam

Category	ELISA Kit
Prices	$489.00
Sizes	1 x 96 tests
Sensitivity	= 0.04 µg/ml
Range	0.039 µg/ml - 40 µg/ml

Standard curve: mean of duplicates (+/- SD) with background reads subtracted

alpha 1 Antitrypsin (SERPINA1) Human SimpleStep ELISA™ Kit - ab189579 from Abcam

Category	ELISA Kit
Prices	$484.00
Sizes	1 x 96 tests
Sensitivity	13 ng/ml
Range	31 ng/ml - 2000 ng/ml

Background-subtracted data values (mean +/- SD) are graphed.

Rat SERPINA1 / Alpha 1 Antitrypsin ELISA Kit (Sandwich ELISA) - LS-F6431 from LifeSpan Bioscience

Category	ELISA Kit
Prices	$740.00
Sizes	1 plate
Sensitivity	3.5 ng/ml
Range	2.048-500 ng/ml

Human SERPINA1 / Alpha 1 Antitrypsin ELISA Kit (Sandwich ELISA) - LS-F4915 from LifeSpan Bioscience

Category	ELISA Kit
Prices	$690.00
Sizes	1 plate
Sensitivity	2.68 ng/ml
Range	2.048-500 ng/ml

Mouse SERPINA1 / Alpha 1 Antitrypsin ELISA Kit (Sandwich ELISA) - LS-F5747 from LifeSpan Bioscience

Category	ELISA Kit
Prices	$700.00
Sizes	1 plate
Sensitivity	31.25 ng/ml
Range	2.048-500 ng/ml

Human SERPINA1 / Alpha 1 Antitrypsin ELISA Kit (Sandwich ELISA) - LS-F10695 from LifeSpan Bioscience

Category	ELISA Kit
Prices	$530.00
Sizes	1 plate
Sensitivity	3.12
Range	2.048-500 ng/ml

Human Serpin A1 DuoSet ELISA - DY1268 from R&D Systems

Category	ELISA Kit
Prices	$649.00
Sizes	1 kit (for 15 Plates)
Range	125.00 - 8,000 pg/mL

Human Alpha-1-Antitrypsin ELISA Kit - abx150622 from Abbexa

Category	ELISA Kit
Sensitivity	1.06 ng/ml
Range	3.125 ng/ml - 200 ng/ml

Alpha 1-Antitrypsin, a1-AT, Human, ELISA Kit - E-EL-H0965 from ARP American Research Products

Category	ELISA Kit
Prices	$522.00
Sizes	96 t
Sensitivity	1.875
Range	3.125-200ng/mL

Alpha-1-antitrypsin, SERPINA1, Human, ELISA Kit - E1697h from ARP American Research Products

Category	ELISA Kit
Prices	$476.00
Sizes	96 t
Range	3.12-200 ng/mL

Alpha1-Antitrypsin, alpha1-AT, Human, ELISA Kit - CSB-E11719h from ARP American Research Products

Category	ELISA Kit
Prices	$495.00, $695.00, $696.00, $699.00
Sizes	48 t, 96 t, 5 x 96t, 10 x 96t
Sensitivity	19.5 nIU/ml
Range	78 nIU/ml -5000 nIU/ml

SERPINA1/A1AT (serpin peptidase inhibitor clade A (alpha-1 antiproteinase antitrypsin) member 1), Human, ELISA Kit - E-EL-H1393 from ARP American Research Products

Category	ELISA Kit
Prices	$617.40
Sizes	96 t
Sensitivity	1.875 ng/mL
Range	3.125-200ng/mL

SERPINA1 (Serine/Cysteine Peptidase Inhibitor Clade A Member 1) , Dog, ELISA Kit - SERPINA1 (Serine/Cysteine Peptidase Inhibitor Clade A Member 1) , Dog, ELISA Kit, E-EL-C0016 from ARP American Research Products

Category	ELISA Kit
Prices	$988.00
Sizes	96 t

SERPINA1 (Human) Matched Antibody Pair - H00005265-AP21 from Acris Antibodies

Category	Antibody Pair
Prices	$610.00
Sizes	1 set

SERPINA1 (Human) ELISA kit - KA0458 from Acris Antibodies

Category	ELISA Kit
Prices	$650.00
Sizes	1 kit

SERPINA1 (Human) ELISA kit - KA0459 from Acris Antibodies

Category	ELISA Kit
Prices	$650.00
Sizes	1 kit

Human Serpin A1 ELISA - ELH-SerpinA1 from RayBiotech

Category	ELISA Kit
Prices	$390.00, $702.00, $1,561.00
Sizes	1 plate kit, 2 plate kit, 5 plate kit
Sensitivity	2 ng/ml
Range	2 ng/ml - 500 ng/ml

Alpha-1-Antitrypsin - MBS071537 from MyBioSource

Category	ELISA Kit
Sensitivity	The sensitivity of this kit is 1.0mumol/L.
Range	The detection range of this kit is 3.12mumol/L-100mumol/L.

Alpha-1-Antitrypsin - MBS093815 from MyBioSource

Category	ELISA Kit
Prices	$435.00, $600.00
Sizes	48 strip wells, 96 strip wells

Alpha-1-Antitrypsin - MBS074107 from MyBioSource

Category	ELISA Kit
Prices	$435.00, $600.00
Sizes	48 strip wells, 96 strip wells

Alpha-1-Antitrypsin - MBS089468 from MyBioSource

Category	ELISA Kit
Prices	$435.00, $600.00
Sizes	48 strip wells, 96 strip wells

Alpha-1-Antitrypsin - MBS060390 from MyBioSource

Category	ELISA Kit
Prices	$435.00, $600.00
Sizes	48 strip wells, 96 strip wells

Alpha-1-Antitrypsin (a1AT), ELISA Kit - MBS9309454 from MyBioSource

Category	ELISA Kit
Prices	$435.00, $600.00, $2,650.00, $5,205.00
Sizes	48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Alpha-1-Antitrypsin (a1AT), ELISA Kit - MBS2020625 from MyBioSource

Category	ELISA Kit
Prices	$390.00, $580.00, $785.00, $3,220.00, $5,840.00
Sizes	24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity	Typically less than 3.3ng/mL.
Range	7.81-500ng/mL

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