SERPINA1

Gene Symbol SERPINA1
Entrez Gene 5265
Alt Symbol A1A, A1AT, AAT, PI, PI1, PRO2275, alpha1AT
Species Human
Gene Type protein-coding
Description serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
Other Description alpha-1 protease inhibitor|alpha-1-antiproteinase|alpha-1-antitrypsin|alpha-1-antitrypsin null|protease inhibitor 1 (anti-elastase), alpha-1-antitrypsin|serine (or cysteine) proteinase inhibitor, clade A, member 1|serpin A1
Swissprots Q9UCM3 Q96BF9 A6PX14 B2RDQ8 Q9P1P0 Q5U0M1 P01009 Q86U18 Q7M4R2 Q53XB8 Q86U19 Q96ES1 Q13672 Q9UCE6 Q0PVP5
Accessions AAA51547 AAB59369 AAB59370 AAB59371 AAB59495 AAF15128 AAP13998 ABA41642 ABC62080 ABR29795 ABS30840 ABS30841 ACB47283 ACR55079 CAJ15161 EAW81570 EAW81571 EAW81572 EAW81573 EAW81574 EAW81575 EAW81576 P01009 AA317159 AF119873 AAF69627 AK026174 AK315637 BAG38005 BC011991 AAH11991 BC015642 AAH15642 BC070163 BG483969 BM844817 BM923322 BP296710 BP300943 BP301274 BT019455 AAV38262 BX161449 CAD61914 BX247968 CAD62306 BX248002 CAD62334 BX248257 CAD62585 BX477352 CD685665 DA427262 DA428299 DA433050 DA433058 DA672472 DA675981 DA966896 DQ682455 ABG73380 FJ830375 ACO55054 GU727620 ADU87622 HQ448245 ADQ32725 K01396 AAB59375 M11465 AAA51546 M26123 AAA51545 V00496 CAA23755 X01683 CAA25838 X02920 CAA26677 X05826 CAA29267 X05827 X17122 CAA34982 NM_000295 NP_000286 NM_001002235 NP_001002235 NM_001002236 NP_001002236 NM_001127700 NP_001121172 NM_001127701 NP_001121173 NM_001127702 NP_001121174 NM_001127703 NP_001121175 NM_001127704 NP_001121176 NM_001127705 NP_001121177 NM_001127706 NP_001121178 NM_001127707 NP_001121179
Function Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.
Subcellular Location Secreted. Endoplasmic reticulum. Note=The S and Z allele are not secreted effectively and accumulate intracellularly in the endoplasmic reticulum.
Tissue Specificity Ubiquitous. Expressed in leukocytes and plasma. {ECO:0000269|PubMed:23826168}.
Top Pathways Complement and coagulation cascades

Human-SERPINA1-cDNA-Clone - DC03263 from Abgent, a WuXi AppTec company

Prices $564.30
Sizes 10 µg
Species Human
Accession BC011991

SERPINA1 - MBS1265632 from MyBioSource

Prices $175.00
Sizes 10ug plasmid + 200ul glycerol stock
Species Human
Accession BC011991

Human SERPINA1 cDNA clone(NM_001127700.1) - CDFH017247 from Creative Biomart

Species Human
Accession NM_001127700.1

Human SERPINA1 cDNA clone(NM_001127701.1) - CDFH017248 from Creative Biomart

Species Human
Accession NM_001127701.1

Human SERPINA1 cDNA clone(NM_001127704.1) - CDFH017249 from Creative Biomart

Species Human
Accession NM_001127704.1

Human SERPINA1 cDNA clone(NM_001127702.1) - CDFH017250 from Creative Biomart

Species Human
Accession NM_001127702.1

Human SERPINA1 cDNA clone(NM_001127703.1) - CDFH017251 from Creative Biomart

Species Human
Accession NM_001127703.1

Human SERPINA1 cDNA clone(NM_001127706.1) - CDFH017252 from Creative Biomart

Species Human
Accession NM_001127706.1

Human SERPINA1 cDNA clone(NM_001127705.1) - CDFH017253 from Creative Biomart

Species Human
Accession NM_001127705.1

Human SERPINA1 cDNA clone(NM_001127707.1) - CDFH017254 from Creative Biomart

Species Human
Accession NM_001127707.1

Human SerpinA1 ORF clone(NM_000295.4) - CDCL186114 from Creative Biomart

Species Human
Accession NM_000295.4

human SERPINA1 ORF clone - CDCH078672 from Creative Biomart

Species Human
Accession NM_000295

human SERPINA1 ORF clone - CDCH078673 from Creative Biomart

Species Human
Accession NM_000295

Human SERPINA1 ORF Clone(NM_001127700.1) - CDCR348870 from Creative Biomart

Species Human
Accession NM_001127700.1

Human SERPINA1 ORF Clone(NM_001127700.1) - CDCR348872 from Creative Biomart

Species Human
Accession NM_001127700.1

Human SERPINA1 ORF Clone(NM_001127701.1) - CDCR348873 from Creative Biomart

Species Human
Accession NM_001127701.1

Human SERPINA1 ORF Clone(NM_001127702.1) - CDCR348874 from Creative Biomart

Species Human
Accession NM_001127702.1

Human SERPINA1 ORF Clone(NM_001127702.1) - CDCR348875 from Creative Biomart

Species Human
Accession NM_001127702.1

Human SERPINA1 ORF Clone(NM_001127701.1) - CDCR348876 from Creative Biomart

Species Human
Accession NM_001127701.1

Human SERPINA1 ORF Clone(NM_001127703.1) - CDCR348877 from Creative Biomart

Species Human
Accession NM_001127703.1

Human SERPINA1 ORF Clone(NM_001127703.1) - CDCR348878 from Creative Biomart

Species Human
Accession NM_001127703.1

Human SERPINA1 ORF Clone(NM_001127704.1) - CDCR348879 from Creative Biomart

Species Human
Accession NM_001127704.1

Human SERPINA1 ORF Clone(NM_001127705.1) - CDCR348880 from Creative Biomart

Species Human
Accession NM_001127705.1

Human SERPINA1 ORF Clone(NM_001127705.1) - CDCR348881 from Creative Biomart

Species Human
Accession NM_001127705.1

Human SERPINA1 ORF Clone(NM_001127704.1) - CDCR348882 from Creative Biomart

Species Human
Accession NM_001127704.1
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