SLC11A2

Gene Symbol	SLC11A2
Entrez Gene	4891
Alt Symbol	DCT1, DMT1, NRAMP2
Species	Human
Gene Type	protein-coding
Description	solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
Other Description	DMT-1|NRAMP 2|divalent cation transporter 1|natural resistance-associated macrophage protein 2|solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2|solute carrier family 11 member 2
Swissprots	Q96J35 Q8IUD7 O94801 O43288 B3KT08 P49281 O60932 B4DK84 F5H741 Q498Z5
Accessions	AAC21460 AAC21461 AIY26913 AIY26914 AIY26915 AIY26916 AIY26917 AIY26918 AIY26919 AIY26920 AIY26921 AIY26922 AIY26923 AIY30320 AIY30321 AIY30322 AIY30323 AIY30324 AIY30325 AIY30326 BAA34374 EAW58159 EAW58160 EAW58161 EAW58162 EAW58163 EAW58164 EAW58165 P49281 AB004857 BAA24933 AB062284 BAB93467 AF046997 AAC18078 AF064484 AAC21459 AJ493662 CAD38517 AK094735 BAG52920 AK128640 BAG54706 AK296445 BAG59096 AK315987 BAH14358 AK316507 BAH14878 AL832886 BC002592 AAH02592 BC100014 AAI00015 CD365137 CK000292 DA417090 DA737206 DA957633 DB350334 DC324894 GQ129269 ACT64403 GQ129270 ACT64404 L37347 AAA79219 XM_005268911 XP_005268968 XM_005268912 XP_005268969 XM_005268913 XP_005268970 XM_005268914 XP_005268971 XM_011538404 XP_011536706 XM_011538405 XP_011536707 XM_011538406 XP_011536708 XR_429104 XR_944555 NM_000617 NP_000608 NM_001174125 NP_001167596 NM_001174126 NP_001167597 NM_001174127 NP_001167598 NM_001174128 NP_001167599 NM_001174129 NP_001167600 NM_001174130 NP_001167601 NR_033421 NR_033422
Function	Important in metal transport, in particular iron. Can also transport manganese, cobalt, cadmium, nickel, vanadium and lead. Involved in apical iron uptake into duodenal enterocytes. Involved in iron transport from acidified endosomes into the cytoplasm of erythroid precursor cells. May play an important role in hepatic iron accumulation and tissue iron distribution. May serve to import iron into the mitochondria. {ECO:0000269|PubMed:17109629, ECO:0000269|PubMed:24448823, ECO:0000269|PubMed:25326704, ECO:0000269|PubMed:25491917}.
Subcellular Location	Isoform 2: Cell membrane {ECO:0000269|PubMed:12475959, ECO:0000269|PubMed:25491917}; Multi- pass membrane protein {ECO:0000305}. Early endosome {ECO:0000269|PubMed:12475959}.
Tissue Specificity	Ubiquitously expressed. Isoform 1 is highly expressed in brain. Isoform 2 is highly expressed in spleen, thymus and pancreas. Isoform 3 and isoform 4 are abundantly expressed in duodenum and kidney. {ECO:0000269|PubMed:12209011, ECO:0000269|PubMed:9642100}.
Top Pathways	Lysosome, Mineral absorption

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Rat SLC11A2 / DMT1 ELISA Kit (Sandwich ELISA) - LS-F8595 from LifeSpan Bioscience Category ELISA Kit Prices $780.00 Sizes 1 plate Sensitivity 0.116 ng/ml Range 0.313-20 ng/ml

Human SLC11A2 / DMT1 ELISA Kit (Sandwich ELISA) - LS-F9571 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.064 ng/ml Range 0.313-20 ng/ml

Human SLC11A2 / DMT1 ELISA Kit (Sandwich ELISA) - LS-F12192 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 15.6 pg/ml Range 0.313-20 ng/ml

Human DMT1 ELISA Kit - abx151328 from Abbexa Category ELISA Kit Sensitivity 0.054 ng/ml Range 0.156 ng/ml - 10 ng/ml

Divalent Metal Transporter 1 (DMT1), Human, ELISA Kit - SEE426Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.112ng/mL Range 0.312-20ng/mL

Natural resistance-associated macrophage protein 2, SLC11A2, Human, ELISA Kit - E0316h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 15.6-1000 pg/mL

solute carrier family 11 (proton-coupled divalent metal ion transporters) , member 2, ELISA Kit - MBS9336917 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ELISA Kit for Divalent Metal Transporter 1 (DMT1) - SEE426Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.059ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

ELISA Kit for Divalent Metal Transporter 1 (DMT1) - SEE426Ra from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.119ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

ELISA Kit for Divalent Metal Transporter 1 (DMT1) - SEE426Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.059ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Rat SLC11A2 / DMT1 ELISA Kit (Custom ELISA) - LS-F14285 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.313-20 ng/ml

Mouse SLC11A2 / DMT1 ELISA Kit (Custom ELISA) - LS-F14284 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.313-20 ng/ml

Human DMT1 ELISA Kit - abx573164 from Abbexa Category ELISA Kit Sensitivity 0.112 ng/ml Range 0.313 ng/ml - 20 ng/ml

SLC11A2 - EKH1678 from Nordic BioSite Sensitivity 9.375pg/ml Range 15.6-1000pg/ml

SLC11A2 ELISA Kit (Human) : 96 Wells (OKEH00377) - OKEH00377 from Aviva Systems Biology Category ELISA Kit Prices $420.00 Sizes 96 wells Sensitivity < 10 pg/mL Range 15.6 - 1,000 pg/mL

Human DMT1 ELISA Kit - E012089 from Biobool Category ELISA Kit Sensitivity The minimum detectable dose of DMT1 is typically less than 0.064ng/mL. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined by adding two

Human SLC11A2 ELISA Kit - E025882 from Biobool Category ELISA Kit

Human Natural resistance-associated macrophage protein 2 ELISA Kit - EK1620 from Signalway Antibody Category ELISA Kit Prices $599.00 Sizes 1x96t Sensitivity less than 10pg/mL Range 15.6-1000 pg/mL

Human Doublesex- and mab-3-related transcription factor 1 (DMRT1) ELISA Kit - AE47071HU from ARP American Research Products Category ELISA Kit Prices $549.00 Sizes 96 t

Human Natural resistance-associated macrophage protein 2 (SLC11A2) ELISA Kit - AE19230HU from ARP American Research Products Category ELISA Kit Prices $549.00 Sizes 96 t Sensitivity 0.055 ng/mL Range 0.156-10 ng/mL

Divalent Metal Transporter 1 (DMT1), ELISA Kit - MBS456116 from MyBioSource Category ELISA Kit Prices $415.00, $550.00, $2,425.00, $4,710.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.112ng/mL Range 0.312-20ng/mL

Natural resistance-associated macrophage protein 2, ELISA Kit - MBS9425481 from MyBioSource Category ELISA Kit Prices $555.00 Sizes 96 tests Sensitivity Less than 10pg/mL Range 15.6-1000 pg/mL

Natural resistance-associated macrophage protein 2, ELISA Kit - MBS765330 from MyBioSource Category ELISA Kit Prices $295.00, $390.00, $1,615.00, $3,015.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 9.375pg/ml Range 15.6-1000pg/ml

Natural resistance-associated macrophage protein 2, ELISA Kit - MBS288992 from MyBioSource Category ELISA Kit Prices $380.00, $500.00, $2,170.00, $3,840.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Range 15.6-1000 pg/mL

Natural resistance-associated macrophage protein 2, ELISA Kit - MBS766022 from MyBioSource Category ELISA Kit Prices $295.00, $390.00, $1,615.00, $3,015.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 9.375pg/ml Range 15.6-1000pg/ml

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