SLC11A2

Gene Symbol SLC11A2
Entrez Gene 4891
Alt Symbol DCT1, DMT1, NRAMP2
Species Human
Gene Type protein-coding
Description solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
Other Description DMT-1|NRAMP 2|divalent cation transporter 1|natural resistance-associated macrophage protein 2|solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2|solute carrier family 11 member 2
Swissprots Q96J35 Q8IUD7 O94801 O43288 B3KT08 P49281 O60932 B4DK84 F5H741 Q498Z5
Accessions AAC21460 AAC21461 AIY26913 AIY26914 AIY26915 AIY26916 AIY26917 AIY26918 AIY26919 AIY26920 AIY26921 AIY26922 AIY26923 AIY30320 AIY30321 AIY30322 AIY30323 AIY30324 AIY30325 AIY30326 BAA34374 EAW58159 EAW58160 EAW58161 EAW58162 EAW58163 EAW58164 EAW58165 P49281 AB004857 BAA24933 AB062284 BAB93467 AF046997 AAC18078 AF064484 AAC21459 AJ493662 CAD38517 AK094735 BAG52920 AK128640 BAG54706 AK296445 BAG59096 AK315987 BAH14358 AK316507 BAH14878 AL832886 BC002592 AAH02592 BC100014 AAI00015 CD365137 CK000292 DA417090 DA737206 DA957633 DB350334 DC324894 GQ129269 ACT64403 GQ129270 ACT64404 L37347 AAA79219 XM_005268911 XP_005268968 XM_005268912 XP_005268969 XM_005268913 XP_005268970 XM_005268914 XP_005268971 XM_011538404 XP_011536706 XM_011538405 XP_011536707 XM_011538406 XP_011536708 XR_429104 XR_944555 NM_000617 NP_000608 NM_001174125 NP_001167596 NM_001174126 NP_001167597 NM_001174127 NP_001167598 NM_001174128 NP_001167599 NM_001174129 NP_001167600 NM_001174130 NP_001167601 NR_033421 NR_033422
Function Important in metal transport, in particular iron. Can also transport manganese, cobalt, cadmium, nickel, vanadium and lead. Involved in apical iron uptake into duodenal enterocytes. Involved in iron transport from acidified endosomes into the cytoplasm of erythroid precursor cells. May play an important role in hepatic iron accumulation and tissue iron distribution. May serve to import iron into the mitochondria. {ECO:0000269|PubMed:17109629, ECO:0000269|PubMed:24448823, ECO:0000269|PubMed:25326704, ECO:0000269|PubMed:25491917}.
Subcellular Location Isoform 2: Cell membrane {ECO:0000269|PubMed:12475959, ECO:0000269|PubMed:25491917}; Multi- pass membrane protein {ECO:0000305}. Early endosome {ECO:0000269|PubMed:12475959}.
Tissue Specificity Ubiquitously expressed. Isoform 1 is highly expressed in brain. Isoform 2 is highly expressed in spleen, thymus and pancreas. Isoform 3 and isoform 4 are abundantly expressed in duodenum and kidney. {ECO:0000269|PubMed:12209011, ECO:0000269|PubMed:9642100}.
Top Pathways Lysosome, Mineral absorption

NRAMP 1 (D-9) - sc-398036 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
NRAMP 1 (D-9): sc-398036. Western blot analysis of NRAMP 1 expression in U-937 whole cell lysate.

NRAMP 1 (E-2) - sc-398077 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
NRAMP 1 (E-2): sc-398077. Western blot analysis of NRAMP 1 expression in U-937 whole cell lysate.

NRAMP 2 (G-5) - sc-166884 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
NRAMP 2 (G-5): sc-166884. Western blot analysis of NRAMP 2 expression in IMR-32 whole cell lysate.

NRAMP 2 (N-20) - sc-16887 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

NRAMP 2 (H-108) - sc-30120 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
NRAMP 2 (H-108): sc-30120. Western blot analysis of NRAMP 2 expression in mouse brain tissue extract.

NRAMP 2 (S-20) - sc-30926 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-DMT1 antibody - ab55735 from Abcam

Prices $384.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
IHC-Fr image of DMT1 staining on mouse duodenum using ab55735 (1:1000). The sections were fixed with paraformaldehyde and permeabilized using 0.1% TritonX in 0.1% PBS. The slides were blocked using 10 % donkey serum for 1 hour at 24°C. ab55735 was diluted 1:1000 using 0.1% TritonX with 0.1x PBS- 10% Donkeys and incubated with the slides at 4°C for 24 hours. The secondary antibody used was donkey polyclonal against mouse IgG conjugated to Alexa Fluor 568 (1:1000)See Abreview

Anti-DMT1 antibody - ab123085 from Abcam

Prices $394.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-DMT1 antibody (ab123085) at 1/100 dilution + Mouse cerebellum tissue lysates at 35 µg

Anti-DMT1 antibody - ab55812 from Abcam

Prices $379.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-DMT1 antibody (ab55812) at 1 µg/ml + Pancreas (Human) Tissue Lysate - adult normal tissue (ab29816) at 10 µgSecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-DMT1 antibody [4C6] - ab117544 from Abcam

Prices $384.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 4C6
ICC/IF image of DMT1 staining on Caco2 cells using ab117544 (1:1000). The cells were fixed with paraformaldehyde and permeabilized using 0.1% TritonX in 0.1% PBS. The cells were blocked using 10 % donkey serum for 1 hour at 24°C. ab117544 was diluted 1:1000 using 0.1% TritonX with 0.1x PBS- 10% Donkeys and incubated with the slides at 4°C for 24 hours. The secondary antibody used was donkey polyclonal against mouse IgG conjugated to Alexa Fluor 488 (undiluted)See Abreview

Anti-SLC11A2 / DMT1 Antibody - LS-C179253 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC11A2 / DMT1 Antibody (clone 4C6) IHC-plus™ - LS-B5484 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 4C6
Anti-SLC11A2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5484 concentration 5 ug/ml.

Anti-SLC11A2 / DMT1 Antibody (aa262-291) - LS-C161124 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Confocal immunofluorescent of SLC11A2 Antibody with HepG2 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).

Anti-SLC11A2 / DMT1 Antibody (C-Terminus) IHC-plus™ - LS-A9282 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-SLC11A2 antibody LS-A9282 IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-SLC11A2 / DMT1 Antibody (Internal) IHC-plus™ - LS-A9281 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-SLC11A2 antibody LS-A9281 IHC of human, pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-SLC11A2 / DMT1 Antibody (4th Cytoplasmic Domain) - LS-C16683 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-SLC11A2 / DMT1 Antibody (4th Cytoplasmic Domain) - LS-C16684 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC11A2 / DMT1 Antibody (C-Terminus) - LS-C16685 from LifeSpan Bioscience

Prices $385.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-SLC11A2 / DMT1 Antibody (C-Terminus) - LS-C16687 from LifeSpan Bioscience

Prices $560.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SLC11A2 / DMT1 Antibody (C-Terminus) - LS-C16688 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC11A2 / DMT1 Antibody (C-Terminus) - LS-C16689 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC11A2 / DMT1 Antibody (C-Terminus) - LS-C16694 from LifeSpan Bioscience

Prices $385.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-SLC11A2 / DMT1 Antibody (N-Terminus) - LS-C46915 from LifeSpan Bioscience

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SLC11A2 / DMT1 Antibody (N-Terminus) - LS-C46916 from LifeSpan Bioscience

Prices $295.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SLC11A2 / DMT1 Antibody (aa262-291, AP) - LS-C269500 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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