| Gene Symbol |
SLC11A2
|
| Entrez Gene |
4891
|
| Alt Symbol |
DCT1, DMT1, NRAMP2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
|
| Other Description |
DMT-1|NRAMP 2|divalent cation transporter 1|natural resistance-associated macrophage protein 2|solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2|solute carrier family 11 member 2
|
| Swissprots |
Q96J35 Q8IUD7 O94801 O43288 B3KT08 P49281 O60932 B4DK84 F5H741 Q498Z5
|
| Accessions |
AAC21460 AAC21461 AIY26913 AIY26914 AIY26915 AIY26916 AIY26917 AIY26918 AIY26919 AIY26920 AIY26921 AIY26922 AIY26923 AIY30320 AIY30321 AIY30322 AIY30323 AIY30324 AIY30325 AIY30326 BAA34374 EAW58159 EAW58160 EAW58161 EAW58162 EAW58163 EAW58164 EAW58165 P49281 AB004857 BAA24933 AB062284 BAB93467 AF046997 AAC18078 AF064484 AAC21459 AJ493662 CAD38517 AK094735 BAG52920 AK128640 BAG54706 AK296445 BAG59096 AK315987 BAH14358 AK316507 BAH14878 AL832886 BC002592 AAH02592 BC100014 AAI00015 CD365137 CK000292 DA417090 DA737206 DA957633 DB350334 DC324894 GQ129269 ACT64403 GQ129270 ACT64404 L37347 AAA79219 XM_005268911 XP_005268968 XM_005268912 XP_005268969 XM_005268913 XP_005268970 XM_005268914 XP_005268971 XM_011538404 XP_011536706 XM_011538405 XP_011536707 XM_011538406 XP_011536708 XR_429104 XR_944555 NM_000617 NP_000608 NM_001174125 NP_001167596 NM_001174126 NP_001167597 NM_001174127 NP_001167598 NM_001174128 NP_001167599 NM_001174129 NP_001167600 NM_001174130 NP_001167601 NR_033421 NR_033422
|
| Function |
Important in metal transport, in particular iron. Can also transport manganese, cobalt, cadmium, nickel, vanadium and lead. Involved in apical iron uptake into duodenal enterocytes. Involved in iron transport from acidified endosomes into the cytoplasm of erythroid precursor cells. May play an important role in hepatic iron accumulation and tissue iron distribution. May serve to import iron into the mitochondria. {ECO:0000269|PubMed:17109629, ECO:0000269|PubMed:24448823, ECO:0000269|PubMed:25326704, ECO:0000269|PubMed:25491917}.
|
| Subcellular Location |
Isoform 2: Cell membrane {ECO:0000269|PubMed:12475959, ECO:0000269|PubMed:25491917}; Multi- pass membrane protein {ECO:0000305}. Early endosome {ECO:0000269|PubMed:12475959}.
|
| Tissue Specificity |
Ubiquitously expressed. Isoform 1 is highly expressed in brain. Isoform 2 is highly expressed in spleen, thymus and pancreas. Isoform 3 and isoform 4 are abundantly expressed in duodenum and kidney. {ECO:0000269|PubMed:12209011, ECO:0000269|PubMed:9642100}.
|
| Top Pathways |
Lysosome, Mineral absorption
|
![Western Blot: DMT1 Overexpression Lysate (Adult Normal) [NBP2-10692] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for DMT1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9958_DMT1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-10692-img0001.jpg)