ALOX12B

Gene Symbol	ALOX12B
Entrez Gene	242
Alt Symbol	12R-LOX, ARCI2
Species	Human
Gene Type	protein-coding
Description	arachidonate 12-lipoxygenase, 12R type
Other Description	12R-lipoxygenase|arachidonate 12-lipoxygenase, 12R-type|epidermis-type lipoxygenase 12
Swissprots	O75342
Accessions	CAC34520 EAW90095 O75342 AF038461 AAC39770 AF059250 AAC79680 BC041058 AAH41058 NM_001139 NP_001130
Function	Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12R)- hydroperoxyeicosatetraenoic acid/(12R)-HPETE and minor stereoisomers. In the skin, acts upstream of ALOXE3 on the lineolate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. May also play a role in the regulation of the expression of airway mucins. {ECO:0000269|PubMed:21558561, ECO:0000269|PubMed:22441738, ECO:0000269|PubMed:9618483}.
Subcellular Location	Cytoplasm {ECO:0000255|PROSITE- ProRule:PRU00726}.
Tissue Specificity	Expressed in B-cells, hair follicles, foreskin keratinocytes and adult skin. Also expressed in psoriatic tissue. {ECO:0000269|PubMed:9618483}.
Top Pathways	Arachidonic acid metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Arachidonate 12-lipoxygenase, 12R-type (ALOX12B), Human, ELISA Kit - E01A1399 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Arachidonate 12 lipoxygenase, 12R type (ALOX12B), ELISA Kit - MBS7237656 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Arachidonate 12-lipoxygenase, 12R-type (ALOX12B), ELISA Kit - MBS7205391 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Arachidonate 12-lipoxygenase, 12R-type (ALOX12B), ELISA Kit - MBS7233861 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Arachidonate 12-lipoxygenase, 12R-type (ALOX12B), ELISA Kit - MBS7220332 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Arachidonate 12-lipoxygenase, 12R-type (ALOX12B), ELISA Kit - MBS7220084 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Arachidonate 12-lipoxygenase, 12R-type (ALOX12B), ELISA Kit - MBS7228029 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Arachidonate 12-lipoxygenase, 12R-type (ALOX12B), ELISA Kit - MBS7251335 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Arachidonate 12-lipoxygenase, 12R-type (ALOX12B), ELISA Kit - MBS7210404 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Arachidonate 12-lipoxygenase, 12R-type (ALOX12B), ELISA Kit - MBS7216821 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Arachidonate 12-lipoxygenase, 12R-type (ALOX12B), ELISA Kit - MBS7238368 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Arachidonate 12-lipoxygenase, 12R-type (ALOX12B), ELISA Kit - MBS7250401 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Arachidonate 12-lipoxygenase, 12R-type (ALOX12B), ELISA Kit - MBS7209442 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human ALOX12B ELISA Kit - E003516 from Biobool Category ELISA Kit

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