ALOX12B

Gene Symbol ALOX12B
Entrez Gene 242
Alt Symbol 12R-LOX, ARCI2
Species Human
Gene Type protein-coding
Description arachidonate 12-lipoxygenase, 12R type
Other Description 12R-lipoxygenase|arachidonate 12-lipoxygenase, 12R-type|epidermis-type lipoxygenase 12
Swissprots O75342
Accessions CAC34520 EAW90095 O75342 AF038461 AAC39770 AF059250 AAC79680 BC041058 AAH41058 NM_001139 NP_001130
Function Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12R)- hydroperoxyeicosatetraenoic acid/(12R)-HPETE and minor stereoisomers. In the skin, acts upstream of ALOXE3 on the lineolate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. May also play a role in the regulation of the expression of airway mucins. {ECO:0000269|PubMed:21558561, ECO:0000269|PubMed:22441738, ECO:0000269|PubMed:9618483}.
Subcellular Location Cytoplasm {ECO:0000255|PROSITE- ProRule:PRU00726}.
Tissue Specificity Expressed in B-cells, hair follicles, foreskin keratinocytes and adult skin. Also expressed in psoriatic tissue. {ECO:0000269|PubMed:9618483}.
Top Pathways Arachidonic acid metabolism

Human ALOX12B full length protein - ab157877 from Abcam

Category Protein
Prices $402.00
Sizes 10 µg
Source Wheat germ
Species Human
ab157877 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Human ALOX12B protein fragment - ab157878 from Abcam

Category Protein
Prices $402.00
Sizes 10 µg
Source Wheat germ
Species Human
ab157878 on a 12.5% SDS-PAGE stained with Coomassie Blue.

ALOX12B Antibody Blocking Peptide - LS-E43 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

Recombinant Human ALOX12B Protein - H00000242-Q01 from Novus Biologicals

Category Protein
Prices $250.00
Sizes 2 µg
Source Wheat Germ
Species Human

Recombinant Human ALOX12B Protein - H00000242-P01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

ALOX12B-Antibody-C-term-Blocking-peptide - BP10099b from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

ALOX12B - H00000242-P01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Species Human

ALOX12B - H00000242-P01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Species Human

ALOX12B - H00000242-Q01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Source in vitro transl.
Species Human

ALOX12B - H00000242-Q01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Source in vitro transl.
Species Human

ALOX12B fusion protein - Ag9852 from Proteintech Group

Category Protein
Prices $199.00
Sizes 50 μg
Source E. coli -derived, PGEX-4T
Species Human

Recombinant Human ALOX12B, GST-tagged - ALOX12B-9590H from Creative Biomart

Category Protein
Source E.coli
Species Human

Recombinant Human ALOX12B, His-tagged - ALOX12B-3608H from Creative Biomart

Category Protein
Source E. Coli or Yeast
Species Human

Recombinant Human Arachidonate 12-lipoxygenase, 12R-type(ALOX12B) - CSB-YP001618HU CSB-EP001618HU CSB-BP001618HU CSB-MP001618HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

Arachidonate 12-lipoxygenase, 12R-type (ALOX12B) , Recombinant Protein - MBS1199675 from MyBioSource

Category Protein
Prices $2,580.00, $2,580.00, $3,000.00, $3,000.00
Sizes 1 mg (E-Coli), 100 µg (Baculovirus), 100 µg (Mammalian-Cell), 1 mg (Yeast)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human

Recombinant Arachidonate-12-Lipoxygenase, 12R Type (ALOX12B) - RPD083Hu01 from Uscn Life Science Inc.

Category Protein
Source E.coli
Species Human

ALOX12B Recombinant Protein Antigen - NBP1-89409PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

ALOX12B Peptide, Human - M34GP00522H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

ALOX12B Recombinant Protein (OPCD00369) - OPCD00369 from Aviva Systems Biology

Category Protein
Source E.coli
Species Human
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