| Gene Symbol | ALOX12B |
|---|---|
| Entrez Gene | 242 |
| Alt Symbol | 12R-LOX, ARCI2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | arachidonate 12-lipoxygenase, 12R type |
| Other Description | 12R-lipoxygenase|arachidonate 12-lipoxygenase, 12R-type|epidermis-type lipoxygenase 12 |
| Swissprots | O75342 |
| Accessions | CAC34520 EAW90095 O75342 AF038461 AAC39770 AF059250 AAC79680 BC041058 AAH41058 NM_001139 NP_001130 |
| Function | Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12R)- hydroperoxyeicosatetraenoic acid/(12R)-HPETE and minor stereoisomers. In the skin, acts upstream of ALOXE3 on the lineolate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. May also play a role in the regulation of the expression of airway mucins. {ECO:0000269|PubMed:21558561, ECO:0000269|PubMed:22441738, ECO:0000269|PubMed:9618483}. |
| Subcellular Location | Cytoplasm {ECO:0000255|PROSITE- ProRule:PRU00726}. |
| Tissue Specificity | Expressed in B-cells, hair follicles, foreskin keratinocytes and adult skin. Also expressed in psoriatic tissue. {ECO:0000269|PubMed:9618483}. |
| Top Pathways | Arachidonic acid metabolism |