| Gene Symbol | DAB2 |
|---|---|
| Entrez Gene | 1601 |
| Alt Symbol | DOC-2, DOC2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) |
| Other Description | adaptor molecule disabled-2|differentially expressed in ovarian carcinoma 2|differentially-expressed protein 2|disabled homolog 2|disabled homolog 2, mitogen-responsive phosphoprotein |
| Swissprots | Q9UK04 Q9BTY0 Q13598 P98082 A6NES5 |
| Accessions | AAF23161 EAW55989 EAW55990 EAW55991 EAW55992 EAW55993 EAW55994 P98082 AF188298 AAF05540 AI739507 AK024965 AK092836 AK130136 AK297984 BAG60293 AK314381 BAG37007 BC003064 AAH03064 BU742719 CB989218 DQ891872 ABM82798 EU176643 ABW03444 L16886 AAA93195 U39050 AAC50824 U53446 AAA98975 NM_001244871 NP_001231800 NM_001343 NP_001334 |
| Function | Adapter protein that functions as clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containg non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several rec |
| Subcellular Location | Cytoplasm. Cytoplasmic vesicle, clathrin- coated vesicle membrane. Membrane, clathrin-coated pit. Note=Colocalizes with large insert-containing isoforms of MYO6 at clathrin-coated pits/vesicles. During mitosis is progressively displaced from the membrane and translocated to the cytoplasm. |
| Tissue Specificity | Expressed in deep invaginations, inclusion cysts and the surface epithelial cells of the ovary. Also expressed in breast epithelial cells, spleen, thymus, prostate, testis, macrophages, fibroblasts, lung epithelial cells, placenta, brain stem, heart and small intestine. Expressed in kidney proximal tubular epithelial cells (at protein level). {ECO:0000269|PubMed:10340382, ECO:0000269|PubMed:15134832, ECO:0000269|PubMed:9620555}. |
| Top Pathways | Endocytosis |