DAB2

Gene Symbol	DAB2
Entrez Gene	1601
Alt Symbol	DOC-2, DOC2
Species	Human
Gene Type	protein-coding
Description	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
Other Description	adaptor molecule disabled-2|differentially expressed in ovarian carcinoma 2|differentially-expressed protein 2|disabled homolog 2|disabled homolog 2, mitogen-responsive phosphoprotein
Swissprots	Q9UK04 Q9BTY0 Q13598 P98082 A6NES5
Accessions	AAF23161 EAW55989 EAW55990 EAW55991 EAW55992 EAW55993 EAW55994 P98082 AF188298 AAF05540 AI739507 AK024965 AK092836 AK130136 AK297984 BAG60293 AK314381 BAG37007 BC003064 AAH03064 BU742719 CB989218 DQ891872 ABM82798 EU176643 ABW03444 L16886 AAA93195 U39050 AAC50824 U53446 AAA98975 NM_001244871 NP_001231800 NM_001343 NP_001334
Function	Adapter protein that functions as clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containg non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several rec
Subcellular Location	Cytoplasm. Cytoplasmic vesicle, clathrin- coated vesicle membrane. Membrane, clathrin-coated pit. Note=Colocalizes with large insert-containing isoforms of MYO6 at clathrin-coated pits/vesicles. During mitosis is progressively displaced from the membrane and translocated to the cytoplasm.
Tissue Specificity	Expressed in deep invaginations, inclusion cysts and the surface epithelial cells of the ovary. Also expressed in breast epithelial cells, spleen, thymus, prostate, testis, macrophages, fibroblasts, lung epithelial cells, placenta, brain stem, heart and small intestine. Expressed in kidney proximal tubular epithelial cells (at protein level). {ECO:0000269|PubMed:10340382, ECO:0000269|PubMed:15134832, ECO:0000269|PubMed:9620555}.
Top Pathways	Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human DAB2 full length protein - ab132218 from Abcam Category Protein Source Wheat germ Species Human

Human DAB2 peptide - ab33440 from Abcam Category Peptide

Human DAB2 peptide - ab45512 from Abcam Category Peptide Species Human

Human DAB2 protein fragment - ab152324 from Abcam Category Protein Source Wheat germ Species Human

DAB2 Blocking Peptide - LS-E27595 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DAB2 Antibody Blocking Peptide - LS-E9886 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human DAB2 Protein - H00001601-P02 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human DAB2 Protein - H00001601-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

DAB2 Partial Recombinant Protein - H00001601-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

DAB2-Antibody-C-term-Blocking-Peptide - BP8987b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

DAB2 blocking peptide - GTX89703-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

DAB2 Peptide - AC21-2415-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

DAB2 / DOC2 - H00001601-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

DAB2 / DOC2 - H00001601-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

DAB2 / DOC2 - H00001601-P02 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

DAB2 / DOC2 - H00001601-P02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

DAB2 / DOC2 - H00001601-P02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

DAB2 / DOC2 - H00001601-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

DAB2 / DOC2 - H00001601-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

DAB2 fusion protein - ag0162 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human Disabled homolog 2(DAB2) - CSB-YP006480HU CSB-EP006480HU CSB-BP006480HU CSB-MP006480HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

DAB2 / DOC2 - TP300481 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

DAB2/DOC2, Peptide - MBS427633 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Rat, Dog, Bovine

DAB2 Recombinant Protein Antigen - NBP2-33915PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

DAB2 Peptide, Human - M34GP04006H from Creative Peptides Category Peptide Source Synthetic. Species Human

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