MTDH

Gene Symbol	MTDH
Entrez Gene	92140
Alt Symbol	3D3, AEG-1, AEG1, LYRIC, LYRIC/3D3
Species	Human
Gene Type	protein-coding
Description	metadherin
Other Description	3D3/LYRIC|astrocyte elevated gene 1|astrocyte elevated gene-1 protein|lysine-rich CEACAM1 co-isolated protein|metastasis adhesion protein|protein LYRIC
Swissprots	Q8TCX3 Q6PK07 Q05DH2 Q86UE4 Q52QU9
Accessions	EAW91760 EAW91761 EAW91762 Q86UE4 AF411226 AAO65771 AF501310 AAP30791 AK000745 AK123083 AK308030 AY082966 AAL92861 AY974040 AAX84832 BC001815 BC009324 AAH09324 BC014977 AAH14977 BC022825 BC023994 BC045642 AAH45642 JF432755 ADZ15972 XM_005251099 XP_005251156 XM_011517367 XP_011515669 XM_011517368 XP_011515670 XM_011517369 XP_011515671 XM_011517370 XP_011515672 NM_178812 NP_848927
Function	Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF- kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance. {ECO:0000269|PubMed:15927426, ECO:0000269|PubMed:16452207, ECO:0000269|PubMed:18316612, ECO:0000269|PubMed:19111877}.
Subcellular Location	Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Cell junction, tight junction {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Cytoplasm, perinuclear region. Note=In epithelial cells, recruited to tight junctions (TJ) during the maturation of the TJ complexes. A nucleolar staining may be due to nuclear targeting of an isoform lacking the transmembrane domain (By similarity). TNF-alpha causes translocation from the cytoplasm to the nucleus. {ECO:0000250}.
Tissue Specificity	Widely expressed with highest levels in muscle-dominating organs such as skeletal muscle, heart, tongue and small intestine and in endocrine glands such as thyroid and adrenal gland. Overexpressed in various cancers including breast, brain, prostate, melanoma and glioblastoma multiforme. {ECO:0000269|PubMed:15927426}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human MTDH / Metadherin ELISA Kit (Sandwich ELISA) - LS-F7720 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.059 ng/ml Range 0.156-10 ng/ml

Human Metadherin ELISA Kit - abx152312 from Abbexa Category ELISA Kit Sensitivity 0.056 ng/ml Range 0.156 ng/ml - 10 ng/ml

Metadherin (MTDH), Human, ELISA Kit - SEC631Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.056ng/mL Range 0.156-10ng/mL

Protein LYRIC, MTDH, Human, ELISA Kit - E1442h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 1.56-100 nmol/L

Metadherin, ELISA Kit - MBS067127 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/ml. Range 0.25 ng/ml - 8 ng/ml.

Metadherin, ELISA Kit - MBS059752 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Metadherin, ELISA Kit - MBS067977 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Metadherin, ELISA Kit - MBS075155 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Metadherin, ELISA Kit - MBS100760 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Metadherin, ELISA Kit - MBS090064 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Metadherin, ELISA Kit - MBS093155 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Metadherin (MTDH), ELISA Kit - MBS2022146 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.059ng/mL. Range 0.156-10ng/mL

ELISA Kit for Metadherin (MTDH) - SEC631Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.059ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

ELISA Kit for Metadherin (MTDH) - SEC631Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.059ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Mouse MTDH / Metadherin ELISA Kit (Custom ELISA) - LS-F17287 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Human MTDH / Metadherin ELISA Kit (Custom ELISA) - LS-F17288 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Rat MTDH / Metadherin ELISA Kit (Custom ELISA) - LS-F17286 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Human Metadherin (MTDH) ELISA Kit - EKU05915 from Biomatik Category ELISA Kit Prices $735.00, $3,234.00, $5,880.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 0.059 ng/mL Range 0.156-10 ng/mL

Human Protein LYRIC ELISA Kit - abx250897 from Abbexa Category ELISA Kit Range 1.56 nmol/l - 100 nmol/l

Metadherin (MTDH), Human, ELISA Kit - DL-MTDH-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 15.6-1,000 pg/mL

Human MTDH ELISA Kit - abx571203 from Abbexa Category ELISA Kit Sensitivity 0.056 ng/ml Range 0.156 ng/ml - 10 ng/ml

Human Protein LYRIC ELISA Kit - EKE52504 from Biomatik Category ELISA Kit Prices $685.40, $2,912.95, $5,483.20 Sizes 96 t, 5x96t, 10x96t Sensitivity The minimum detectable dose of this kit is typically less than 0.092 nmol/L Range 1.56-100 nmol/L

MTDH - EKH3212 from Nordic BioSite Sensitivity 0.938pmol/ml Range 1.56-100pmol/ml

Human MTDH ELISA Kit - E024221 from Biobool Category ELISA Kit Sensitivity Typically less than 0.059ng/mL.

MTDH ELISA Kit (Human) (OKEH04866) - OKEH04866 from Aviva Systems Biology Category ELISA Kit Prices $425.00 Sizes 96 wells Sensitivity < 0.78 nmol/L Range 1.56 - 100 nmol/L

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