| Gene Symbol |
MTDH
|
| Entrez Gene |
92140
|
| Alt Symbol |
3D3, AEG-1, AEG1, LYRIC, LYRIC/3D3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
metadherin
|
| Other Description |
3D3/LYRIC|astrocyte elevated gene 1|astrocyte elevated gene-1 protein|lysine-rich CEACAM1 co-isolated protein|metastasis adhesion protein|protein LYRIC
|
| Swissprots |
Q8TCX3 Q6PK07 Q05DH2 Q86UE4 Q52QU9
|
| Accessions |
EAW91760 EAW91761 EAW91762 Q86UE4 AF411226 AAO65771 AF501310 AAP30791 AK000745 AK123083 AK308030 AY082966 AAL92861 AY974040 AAX84832 BC001815 BC009324 AAH09324 BC014977 AAH14977 BC022825 BC023994 BC045642 AAH45642 JF432755 ADZ15972 XM_005251099 XP_005251156 XM_011517367 XP_011515669 XM_011517368 XP_011515670 XM_011517369 XP_011515671 XM_011517370 XP_011515672 NM_178812 NP_848927
|
| Function |
Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF- kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance. {ECO:0000269|PubMed:15927426, ECO:0000269|PubMed:16452207, ECO:0000269|PubMed:18316612, ECO:0000269|PubMed:19111877}.
|
| Subcellular Location |
Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Cell junction, tight junction {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Cytoplasm, perinuclear region. Note=In epithelial cells, recruited to tight junctions (TJ) during the maturation of the TJ complexes. A nucleolar staining may be due to nuclear targeting of an isoform lacking the transmembrane domain (By similarity). TNF-alpha causes translocation from the cytoplasm to the nucleus. {ECO:0000250}.
|
| Tissue Specificity |
Widely expressed with highest levels in muscle-dominating organs such as skeletal muscle, heart, tongue and small intestine and in endocrine glands such as thyroid and adrenal gland. Overexpressed in various cancers including breast, brain, prostate, melanoma and glioblastoma multiforme. {ECO:0000269|PubMed:15927426}.
|