Gene Symbol | C5AR2 |
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Entrez Gene | 27202 |
Alt Symbol | C5L2, GPF77, GPR77 |
Species | Human |
Gene Type | protein-coding |
Description | complement component 5a receptor 2 |
Other Description | C5a anaphylatoxin chemotactic receptor 2|C5a anaphylatoxin chemotactic receptor C5L2|G protein-coupled receptor 77|G protein-coupled receptor C5L2 |
Swissprots | Q9P296 B2RA09 |
Accessions | AAK12640 AAP23197 CAJ33695 EAW57472 Q9P296 AB038237 BAA95414 AK313994 BAG36706 BC067477 AAH67477 BC067478 AAH67478 BC067479 AAH67479 BC067480 AAH67480 BP370117 DA673976 XM_011526736 XP_011525038 XM_011526737 XP_011525039 NM_001271749 NP_001258678 NM_001271750 NP_001258679 NM_018485 NP_060955 |
Function | Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways. {ECO:0000269|PubMed:11773063, ECO:0000269|PubMed:15833747, ECO:0000269|PubMed:19615750}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:19615750}; Multi-pass membrane protein {ECO:0000269|PubMed:19615750}. |
Tissue Specificity | Frontal cortex, hippocampus, hypothalamus, pons and liver. {ECO:0000269|PubMed:11090875, ECO:0000269|PubMed:11165367}. |
C5L2 CRISPR/Cas9 KO Plasmid (h) - sc-410578 from Santa Cruz Biotechnology
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C5L2 HDR Plasmid (h) - sc-410578-HDR from Santa Cruz Biotechnology
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C5L2 Double Nickase Plasmid (h) - sc-410578-NIC from Santa Cruz Biotechnology
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C5L2 Double Nickase Plasmid (h2) - sc-410578-NIC-2 from Santa Cruz Biotechnology
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C5L2 CRISPR Activation Plasmid (h) - sc-410578-ACT from Santa Cruz Biotechnology
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C5L2 CRISPR Activation Plasmid (h2) - sc-410578-ACT-2 from Santa Cruz Biotechnology
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C5L2 Lentiviral Activation Particles (h) - sc-410578-LAC from Santa Cruz Biotechnology
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C5L2 Lentiviral Activation Particles (h2) - sc-410578-LAC-2 from Santa Cruz Biotechnology
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C5L2 siRNA (h) - sc-105165 from Santa Cruz Biotechnology
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C5L2 shRNA Plasmid (h) - sc-105165-SH from Santa Cruz Biotechnology
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C5L2 shRNA (h) Lentiviral Particles - sc-105165-V from Santa Cruz Biotechnology
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C5L2/GPR77 RNAi - H00027202-R02 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN9616 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9616 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00988 from Sigma-Aldrich
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C5AR2 siRNA (Human) - CRH9022 from Cohesion Biosciences
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C5AR2 - MBS8237711 from MyBioSource
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shRNA set against Human GPR77 (NM_018485.1) - SHH307022 from Creative biogene
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shRNA set against Human GPR77(NM_018485.1) - SHH100883 from Creative biogene
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Human C5AR2 siRNA - orb269524 from Biorbyt
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C5AR2 shRNA Plasmid (Human) - CHH9022 from Cohesion Biosciences
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GPR77 miRNA 3'UTR clone - MiUTR3H-10909 from Creative biogene
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