| Gene Symbol |
SARNP
|
| Entrez Gene |
84324
|
| Alt Symbol |
CIP29, HCC1, HSPC316, THO1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SAP domain containing ribonucleoprotein
|
| Other Description |
SAP domain-containing ribonucleoprotein|cytokine induced protein 29 kDa|cytokine-induced protein of 29 kDa|hepatocellular carcinoma 1|nuclear protein Hcc-1|proliferation associated cytokine-inducible protein CIP29|proliferation-associated cytokine-inducible protein CIP29
|
| Swissprots |
A8K393 P82979 Q9P066
|
| Accessions |
CAC37950 EAW96838 P82979 AF161434 AAF28994 AF486281 AAM09686 AK222719 AK290508 BAF83197 BC007099 AAH07099 BC093051 AAH93051 BI520421 EU446946 ABZ92475 NM_033082 NP_149073 NR_026722 NR_026723
|
| Function |
Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single- stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {EC
|
| Subcellular Location |
Nucleus. Nucleus speckle.
|
| Tissue Specificity |
Low expression in spleen, liver, pancreas, testis, thymus, heart, and kidney. Increased levels are seen in hepatocellular carcinoma and pancreatic adenocarcinoma. {ECO:0000269|PubMed:11356193}.
|