Gene Symbol | SARNP |
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Entrez Gene | 84324 |
Alt Symbol | CIP29, HCC1, HSPC316, THO1 |
Species | Human |
Gene Type | protein-coding |
Description | SAP domain containing ribonucleoprotein |
Other Description | SAP domain-containing ribonucleoprotein|cytokine induced protein 29 kDa|cytokine-induced protein of 29 kDa|hepatocellular carcinoma 1|nuclear protein Hcc-1|proliferation associated cytokine-inducible protein CIP29|proliferation-associated cytokine-inducible protein CIP29 |
Swissprots | A8K393 P82979 Q9P066 |
Accessions | CAC37950 EAW96838 P82979 AF161434 AAF28994 AF486281 AAM09686 AK222719 AK290508 BAF83197 BC007099 AAH07099 BC093051 AAH93051 BI520421 EU446946 ABZ92475 NM_033082 NP_149073 NR_026722 NR_026723 |
Function | Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single- stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {EC |
Subcellular Location | Nucleus. Nucleus speckle. |
Tissue Specificity | Low expression in spleen, liver, pancreas, testis, thymus, heart, and kidney. Increased levels are seen in hepatocellular carcinoma and pancreatic adenocarcinoma. {ECO:0000269|PubMed:11356193}. |
CIP29 CRISPR/Cas9 KO Plasmid (h) - sc-410195 from Santa Cruz Biotechnology
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CIP29 HDR Plasmid (h) - sc-410195-HDR from Santa Cruz Biotechnology
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CIP29 Double Nickase Plasmid (h) - sc-410195-NIC from Santa Cruz Biotechnology
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CIP29 Double Nickase Plasmid (h2) - sc-410195-NIC-2 from Santa Cruz Biotechnology
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CIP29 CRISPR Activation Plasmid (h) - sc-410195-ACT from Santa Cruz Biotechnology
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CIP29 CRISPR Activation Plasmid (h2) - sc-410195-ACT-2 from Santa Cruz Biotechnology
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CIP29 Lentiviral Activation Particles (h) - sc-410195-LAC from Santa Cruz Biotechnology
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CIP29 Lentiviral Activation Particles (h2) - sc-410195-LAC-2 from Santa Cruz Biotechnology
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CIP29 siRNA (h) - sc-96155 from Santa Cruz Biotechnology
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CIP29 shRNA Plasmid (h) - sc-96155-SH from Santa Cruz Biotechnology
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CIP29 shRNA (h) Lentiviral Particles - sc-96155-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU224131 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN18852 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18852 from Sigma-Aldrich
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SARNP siRNA (Human) - CRJ3444 from Cohesion Biosciences
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CIP29 RNAi - H00084324-R01 from Novus Biologicals
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SARNP - MBS8238328 from MyBioSource
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shRNA set against Human SARNP (NM_033082.3) - SHH401904 from Creative biogene
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SARNP shRNA Plasmid (Human) - CHJ3444 from Cohesion Biosciences
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SARNP miRNA 3'UTR clone - MiUTR3H-10987 from Creative biogene
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