Gene Symbol |
IL13RA1
|
Entrez Gene |
3597
|
Alt Symbol |
CD213A1, IL-13Ra, NR4
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
interleukin 13 receptor, alpha 1
|
Other Description |
CD213a1 antigen|CT19|IL-13 receptor subunit alpha-1|IL-13R subunit alpha-1|IL-13R-alpha-1|IL13 receptor alpha-1 chain|bB128O4.2.1 (interleukin 13 receptor, alpha 1)|cancer/testis antigen 19|interleukin-13 receptor subunit alpha-1
|
Swissprots |
O95646 Q9UDY5 Q99656 Q5JSL4 P78552
|
Accessions |
EAW89893 EAW89894 P78552 AB209849 BAD93086 AK123515 BAC85635 AK296958 BAG59502 AK313467 BAG36253 BC009960 AAH09960 BC015768 AAH15768 DQ893454 ABM84380 DQ896296 ABM87295 U81379 AAD00510 U81380 AAD00511 Y09328 CAA70508 Y10659 CAA71669 XM_011531336 XP_011529638 XM_011531337 XP_011529639 NM_001560 NP_001551
|
Function |
Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity.
|
Subcellular Location |
Membrane; Single-pass type I membrane protein.
|
Tissue Specificity |
Ubiquitous. Highest levels in heart, liver, skeletal muscle and ovary; lowest levels in brain, lung and kidney. Also found in B-cells, T-cells and endothelial cells.
|
Top Pathways |
Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway
|