Gene Symbol | IL13RA1 |
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Entrez Gene | 3597 |
Alt Symbol | CD213A1, IL-13Ra, NR4 |
Species | Human |
Gene Type | protein-coding |
Description | interleukin 13 receptor, alpha 1 |
Other Description | CD213a1 antigen|CT19|IL-13 receptor subunit alpha-1|IL-13R subunit alpha-1|IL-13R-alpha-1|IL13 receptor alpha-1 chain|bB128O4.2.1 (interleukin 13 receptor, alpha 1)|cancer/testis antigen 19|interleukin-13 receptor subunit alpha-1 |
Swissprots | O95646 Q9UDY5 Q99656 Q5JSL4 P78552 |
Accessions | EAW89893 EAW89894 P78552 AB209849 BAD93086 AK123515 BAC85635 AK296958 BAG59502 AK313467 BAG36253 BC009960 AAH09960 BC015768 AAH15768 DQ893454 ABM84380 DQ896296 ABM87295 U81379 AAD00510 U81380 AAD00511 Y09328 CAA70508 Y10659 CAA71669 XM_011531336 XP_011529638 XM_011531337 XP_011529639 NM_001560 NP_001551 |
Function | Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity. |
Subcellular Location | Membrane; Single-pass type I membrane protein. |
Tissue Specificity | Ubiquitous. Highest levels in heart, liver, skeletal muscle and ovary; lowest levels in brain, lung and kidney. Also found in B-cells, T-cells and endothelial cells. |
Top Pathways | Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway |
IL-13Rα1 CRISPR/Cas9 KO Plasmid (h) - sc-405042 from Santa Cruz Biotechnology
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IL-13Rα1 HDR Plasmid (h) - sc-405042-HDR from Santa Cruz Biotechnology
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IL-13Rα1 Double Nickase Plasmid (h) - sc-405042-NIC from Santa Cruz Biotechnology
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IL-13Rα1 Double Nickase Plasmid (h2) - sc-405042-NIC-2 from Santa Cruz Biotechnology
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IL-13Rα1 CRISPR Activation Plasmid (h) - sc-405042-ACT from Santa Cruz Biotechnology
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IL-13Rα1 CRISPR Activation Plasmid (h2) - sc-405042-ACT-2 from Santa Cruz Biotechnology
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IL-13Rα1 Lentiviral Activation Particles (h) - sc-405042-LAC from Santa Cruz Biotechnology
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IL-13Rα1 Lentiviral Activation Particles (h2) - sc-405042-LAC-2 from Santa Cruz Biotechnology
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IL-13Rα1 siRNA (h) - sc-63337 from Santa Cruz Biotechnology
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IL-13Rα1 shRNA Plasmid (h) - sc-63337-SH from Santa Cruz Biotechnology
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IL-13Rα1 shRNA (h) Lentiviral Particles - sc-63337-V from Santa Cruz Biotechnology
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IL-13 R alpha 1 RNAi - H00003597-R02 from Novus Biologicals
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MISSION® esiRNA - EHU029151 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10570 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10570 from Sigma-Aldrich
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IL13RA1 siRNA (Human) - CRH2406 from Cohesion Biosciences
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IL13RA1 - MBS8241093 from MyBioSource
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shRNA set against Human IL13RA1 (NM_001560.2) - SHH318237 from Creative biogene
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shRNA set against Human IL13RA1(NM_001560.2) - SHL170886 from Creative biogene
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IL13RA1 shRNA Plasmid (Human) - CHH2406 from Cohesion Biosciences
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IL13RA1 miRNA 3'UTR clone - MiUTR1H-04875 from Creative biogene
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