| Gene Symbol | Cflar |
|---|---|
| Entrez Gene | 12633 |
| Alt Symbol | 2310024N18Rik, A430105C05Rik, CLARP, Cash, Casper, ENSMUSG00000072980, FLAME, FLAME-1, Flip, Gm9845, I-FLICE, MRIT, c-Flip |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | CASP8 and FADD-like apoptosis regulator |
| Other Description | FADD-like antiapoptotic molecule 1|MACH-related inducer of toxicity|caspase homolog|caspase-eight-related protein|caspase-like apoptosis regulatory protein|cellular FLICE-like inhibitory protein|inhibitor of FLICE|usurpin |
| Swissprots | O35733 O35707 O35732 D3Z0W6 |
| Accessions | CAW32368 CAW32382 EDL00095 EDL00096 EDL00097 EDL00098 O35732 AK009498 AK020765 AK053567 AK142078 AK143812 BAE25546 AK152515 AK161120 AK161220 BAE36245 BB615039 BB856464 BC023121 BC029223 AAH29223 BC085105 AAH85105 BE944648 U97076 AAC53281 Y14041 CAA74368 Y14042 CAA74369 XM_006495635 XP_006495698 XM_011238420 XP_011236722 XM_011238421 XP_011236723 XM_011238422 XP_011236724 XM_011238423 XP_011236725 NM_001289704 NP_001276633 NM_001293804 NP_001280733 NM_001293805 NP_001280734 NM_009805 NP_033935 NM_207653 NP_997536 |
| Function | Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity (By similarity). {ECO:0000250}. |
| Tissue Specificity | Highly expressed in heart. |
| Top Pathways | Apoptosis, Chagas disease (American trypanosomiasis), TNF signaling pathway |
FLIP S/L CRISPR/Cas9 KO Plasmid (m) - sc-419638 from Santa Cruz Biotechnology
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FLIP S/L HDR Plasmid (m) - sc-419638-HDR from Santa Cruz Biotechnology
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FLIP S/L Double Nickase Plasmid (m) - sc-419638-NIC from Santa Cruz Biotechnology
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FLIP S/L Double Nickase Plasmid (m2) - sc-419638-NIC-2 from Santa Cruz Biotechnology
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FLIP S/L CRISPR Activation Plasmid (m) - sc-419638-ACT from Santa Cruz Biotechnology
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FLIP S/L CRISPR Activation Plasmid (m2) - sc-419638-ACT-2 from Santa Cruz Biotechnology
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FLIP S/L Lentiviral Activation Particles (m) - sc-419638-LAC from Santa Cruz Biotechnology
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FLIP S/L Lentiviral Activation Particles (m2) - sc-419638-LAC-2 from Santa Cruz Biotechnology
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FLIP S/L siRNA (m) - sc-35389 from Santa Cruz Biotechnology
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FLIP S/L shRNA Plasmid (m) - sc-35389-SH from Santa Cruz Biotechnology
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FLIP S/L shRNA (m) Lentiviral Particles - sc-35389-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN28643 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND28643 from Sigma-Aldrich
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CFLAR siRNA (Mouse) - CRM0680 from Cohesion Biosciences
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CFLAR - MBS8228151 from MyBioSource
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shRNA set against Mouse CFLAR (NM_009805.4) - SHH262509 from Creative biogene
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shRNA set against Mouse Cflar(NM_009805.4) - SHG169105 from Creative biogene
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shRNA set against Mouse Cflar(NM_207653.3) - SHG172617 from Creative biogene
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Mouse CFLAR siRNA - orb280156 from Biorbyt
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CFLAR shRNA Plasmid (Mouse) - CHM0680 from Cohesion Biosciences
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CFLAR miRNA 3'UTR clone - MiUTR1M-02972 from Creative biogene
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CFLAR miRNA 3'UTR clone - MiUTR1M-02973 from Creative biogene
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