FBL

Gene Symbol	FBL
Entrez Gene	2091
Alt Symbol	FIB, FLRN, RNU3IP1
Species	Human
Gene Type	protein-coding
Description	fibrillarin
Other Description	34 kDa nucleolar scleroderma antigen|34-kD nucleolar scleroderma antigen|RNA, U3 small nucleolar interacting protein 1|histone-glutamine methyltransferase|rRNA 2'-O-methyltransferase fibrillarin
Swissprots	Q6IAT5 B5BUE8 O75259 P22087 Q9UPI6
Accessions	AAC28913 AAD15623 EAW56925 P22087 AB451384 BAG70198 AI085380 AK296950 BAG59496 AK308649 BC015218 AAH15218 BC019260 AAH19260 BC019609 AAH19609 BG831506 BT006830 AAP35476 BT020144 AAV38946 CR457069 CAG33350 DQ892314 ABM83240 DQ895517 ABM86443 M59849 AAA52453 X56597 CAA39935 XM_005258651 XP_005258708 XM_011526623 XP_011524925 XM_011548798 XP_011547100 XM_011548799 XP_011547101 NM_001436 NP_001427
Function	S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ104me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus (PubMed:24352239). {ECO:0000269|PubMed:24352239}.
Subcellular Location	Nucleus, nucleolus {ECO:0000269|PubMed:14583623, ECO:0000269|PubMed:2026646, ECO:0000269|PubMed:2414294, ECO:0000269|PubMed:24352239}. Note=Fibrillar region of the nucleolus.
Top Pathways	Ribosome biogenesis in eukaryotes

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Fibrillarin peptide - ab13745 from Abcam Category Peptide

Human Fibrillarin protein fragment - ab99443 from Abcam Category Protein Source E. coli Species Human

FBL / FIB / Fibrillarin Antibody Blocking Peptide - LS-E7088 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FBL / FIB / Fibrillarin Antibody Blocking Peptide - LS-E27940 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FBL / FIB / Fibrillarin Antibody Blocking Peptide - LS-E27941 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Fibrillarin Recombinant Protein - H00002091-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Species Human

Recombinant Human Fibrillarin Protein - NBP1-48594 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 10 µg, 50 µg Source E. coli Species Human

FBL-Antibody-Center-E120-Blocking-Peptide - BP2776c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

FBL Protein (OPPA02512) - OPPA02512 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 1 µg Source E. Coli

Human FBL protein - orb168331 from Biorbyt Category Protein Prices $170.00, $289.00, $1,148.00 Sizes 1 μg, 5 μg, 50 μg Source E. coli

FBL protein (His tag) - 80R-1483 from Fitzgerald Category Protein Prices $255.00 Sizes 10 µg Source E.coli

Fibrillarin Blocking Peptide - 33R-3279 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Fibrillarin Peptide - AC21-2709-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Fibrillarin Peptide - AC21-2710-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

FBL (83-321, His-tag) - AR09659PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 50 µg Source E. coli Species Human

FBL (83-321, His-tag) - AR09659PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 10 µg Source E. coli Species Human

FBL - H00002091-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

FBL - H00002091-P01-10 from Acris Antibodies Category Protein Prices $340.00 Sizes 10 µg Source in vitro transl. Species Human

FBL - H00002091-P01-25 from Acris Antibodies Category Protein Prices $460.00 Sizes 25 µg Source in vitro transl. Species Human

Fibrillarin, Human Recombinant - 228-12583-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Species Human

Recombinant Human Fibrillarin - 228-12583-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Escherichia Coli. Species Human

Recombinant Human Fibrillarin - 228-12583-3 from RayBiotech Category Protein Prices $1,448.00 Sizes 3 µg Source Escherichia Coli. Species Human

FBL, 83-321aa, Human, His tag, E.coli - 01-1770 from ARP American Research Products Category Protein Prices $159.00, $369.00, $849.00 Sizes 2 µg, 10 µg, 50 µg Species Human

FBL Peptide - 43-078P from ProSci Category Peptide Species Human

FBL Peptide - 43-079P from ProSci Category Peptide Species Human

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