Gene Symbol | SPRY2 |
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Entrez Gene | 10253 |
Alt Symbol | hSPRY2 |
Species | Human |
Gene Type | protein-coding |
Description | sprouty homolog 2 (Drosophila) |
Other Description | protein sprouty homolog 2|sprouty 2|spry-2 |
Swissprots | B2R9J9 Q5T6Z7 O43597 |
Accessions | EAW80601 O43597 AF039843 AAC04258 AK313810 BAG36546 AL713749 CAD28524 AM392994 CAL37872 AM393598 CAL38475 BC004205 AAH04205 BC015745 AAH15745 BX648582 XM_005266217 XP_005266274 XM_006719753 XP_006719816 XM_011534867 XP_011533169 NM_005842 NP_005833 |
Function | May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis. {ECO:0000269|PubMed:10887178}. |
Subcellular Location | Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10887178}. Cell projection, ruffle membrane {ECO:0000269|PubMed:10887178}. Note=Associated with microtubules in unstimulated cells but is translocated to the membrane ruffles in cells stimulated ith EGF (epidermal growth factor). |
Top Pathways | Jak-STAT signaling pathway, MicroRNAs in cancer |
Sprouty 2 CRISPR/Cas9 KO Plasmid (h) - sc-401087 from Santa Cruz Biotechnology
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Sprouty 2 HDR Plasmid (h) - sc-401087-HDR from Santa Cruz Biotechnology
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Sprouty 2 Double Nickase Plasmid (h) - sc-401087-NIC from Santa Cruz Biotechnology
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Sprouty 2 Double Nickase Plasmid (h2) - sc-401087-NIC-2 from Santa Cruz Biotechnology
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Sprouty 2 CRISPR Activation Plasmid (h) - sc-401087-ACT from Santa Cruz Biotechnology
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Sprouty 2 CRISPR Activation Plasmid (h2) - sc-401087-ACT-2 from Santa Cruz Biotechnology
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Sprouty 2 Lentiviral Activation Particles (h) - sc-401087-LAC from Santa Cruz Biotechnology
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Sprouty 2 Lentiviral Activation Particles (h2) - sc-401087-LAC-2 from Santa Cruz Biotechnology
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Sprouty 2 siRNA (h) - sc-41037 from Santa Cruz Biotechnology
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Sprouty 2 shRNA Plasmid (h) - sc-41037-SH from Santa Cruz Biotechnology
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Sprouty 2 shRNA (h) Lentiviral Particles - sc-41037-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU045261 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20530 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20530 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06561 from Sigma-Aldrich
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SPRY2 siRNA (Human) - CRH6940 from Cohesion Biosciences
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SPRY2 RNAi - H00010253-R01 from Novus Biologicals
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SPRY2 - MBS8207562 from MyBioSource
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shRNA set against Human SPRY2 (NM_005842.2) - SHH417356 from Creative biogene
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shRNA set against Human SPRY2(NM_005842.2) - SHL031184 from Creative biogene
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Human SPRY2 siRNA - orb267442 from Biorbyt
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SPRY2 shRNA Plasmid (Human) - CHH6940 from Cohesion Biosciences
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SPRY2 miRNA 3'UTR clone - MiUTR1H-09878 from Creative biogene
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