KDM5B

Gene Symbol KDM5B
Entrez Gene 10765
Alt Symbol CT31, JARID1B, PLU-1, PLU1, PPP1R98, PUT1, RBBP2H1A
Species Human
Gene Type protein-coding
Description lysine (K)-specific demethylase 5B
Other Description RBP2-H1|cancer/testis antigen 31|histone demethylase JARID1B|jumonji, AT rich interactive domain 1B|jumonji/ARID domain-containing protein 1B|lysine-specific demethylase 5B|protein phosphatase 1, regulatory subunit 98|putative DNA/chromatin binding motif|retinoblastoma-binding protein 2 homolog 1|retinoblastoma-binding protein 2, homolog 1A
Swissprots Q15752 Q9UGL1 Q9Y3Q5 O95811
Accessions AAQ82849 EAW91432 EAW91433 EAW91434 EAW91435 Q9UGL1 AB015348 BAA34803 AF087481 AAD16061 AJ132440 CAB43532 AJ243706 CAB63108 AK001400 BAG50904 AK022521 BAG51084 AK022553 BAG51090 AK074250 AK122752 BAG53706 AK125746 AL133040 CAB61368 AL133048 CAB61375 AL133072 CAB61395 AL137622 CAB70847 AL833515 BC156049 AAI56050 BC157031 AAI57032 CF593335 XM_011509087 XP_011507389 XM_011509088 XP_011507390 XM_011509089 XP_011507391 XM_011509090 XP_011507392 XM_011509091 XP_011507393 XM_011509092 XP_011507394 NM_006618 NP_006609
Function Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity). {ECO:0000250|UniProtKB:Q80Y84, ECO:0000269|PubMed:12657635, ECO:0000269|PubMed:16645588, ECO:0000269|PubMed:17320161, ECO:0000269|PubMed:17363312}.
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00355, ECO:0000255|PROSITE-ProRule:PRU00537, ECO:0000269|PubMed:10336460, ECO:0000269|PubMed:12237901}.
Tissue Specificity Ubiquitously expressed, with highest levels in testis. Down-regulated in melanoma and glioblastoma. Up-regulated in breast cancer (at protein level). {ECO:0000269|PubMed:10336460, ECO:0000269|PubMed:10616211, ECO:0000269|PubMed:10878660, ECO:0000269|PubMed:12237901, ECO:0000269|PubMed:15803180}.

JARID1B Antibody - 3273 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from MCF-7, T-47D and COS cells using JARID1B Antibody.

PLU-1 (H-180) - sc-67035 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

PLU-1 (P-18) - sc-31613 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

PLU-1 (N-19) - sc-31612 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

PLU-1 (JARIA3D4) - sc-81358 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
PLU-1 (JARIA3D4): sc-81358 Western Blot analysis of human recombinant PLU-1 fusion protein.

Anti-KDM5B / PLU1 / Jarid1B antibody - ab56759 from Abcam

Prices $394.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
PLU1 / Jarid1B antibody (ab56759) used in immunohistochemistry at 1ug/ml on formalin fixed and paraffin embedded human colon.

Anti-KDM5B / PLU1 / Jarid1B antibody - ab198884 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-KDM5B / PLU1 / Jarid1B antibody (ab198884) at 1/200 dilutionLane 1 : HeLa cell lysateLane 2 : MCF7 cell lysateLysates/proteins at 40 µg per lane.developed using the ECL technique

Anti-KDM5B / PLU1 / Jarid1B antibody - ab123430 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-KDM5B / PLU1 / Jarid1B antibody (ab123430) at 1/100 dilution + Mouse testis tissue lysate at 35 µg

Anti-KDM5B / PLU1 / Jarid1B antibody - ab84883 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human Jarid1B in a formalin-fixed paraffin-embedded section of human prostate carcinoma by Immunohistochemistry using ab84883 at a dilution of 1:500. Detection: DAB staining.

Anti-KDM5B / PLU1 / Jarid1B antibody - ab186056 from Abcam

Prices $376.00
Sizes 500 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of methanol-fixed HeLa cells, labeling KDM5B / PLU1 / Jarid1B with either A) Control without primary antibody, or B) ab186056 at 10 µg/ml. As secondary antibody goat anti-rabbit IgG FITC was used at a 1/200 dilution.

Anti-KDM5B / PLU1 / Jarid1B antibody [EPR12704] - ab181089 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR12704
Immunofluorescent analysis of HeLa cells (-20°C Acetone-fixed) labeling KDM5B / PLU1 / Jarid1B with ab181089 at 1/100 dilution followed by Goat anti rabbit IgG (Alexa Fluor® 488) secondary antibody at 1/200 dilution. Counter-stained with DAPI (blue).

Anti-KDM5B / PLU1 / Jarid1B antibody [JARIA3D4] - ab50775 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone JARIA3D4
Anti-KDM5B / PLU1 / Jarid1B antibody [JARIA3D4] (ab50775) + Immunizing recombinant fragment

Anti-KDM5B / JARID1B Antibody - LS-C71156 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-KDM5B / JARID1B Antibody - LS-C71157 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-KDM5B / JARID1B Antibody (Biotin) - LS-C181913 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-KDM5B / JARID1B Antibody (DY488) - LS-C181915 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-KDM5B / JARID1B Antibody (HRP) - LS-C181916 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-KDM5B / JARID1B Antibody (DY550) - LS-C181917 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-KDM5B / JARID1B Antibody (clone JARIA3D4) - LS-C184341 from LifeSpan Bioscience

Prices $335.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone JARIA3D4

Anti-KDM5B / JARID1B Antibody (aa191-225, AP) - LS-C215313 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KDM5B / JARID1B Antibody (aa191-225, APC) - LS-C215314 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KDM5B / JARID1B Antibody (aa191-225, FITC) - LS-C215315 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KDM5B / JARID1B Antibody (aa191-225, PE) - LS-C215316 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KDM5B / JARID1B Antibody (aa231-320, Azide-free) - LS-C327676 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-KDM5B / JARID1B Antibody (aa191-225) - LS-C329703 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Search more