KDM5B

Gene Symbol	KDM5B
Entrez Gene	10765
Alt Symbol	CT31, JARID1B, PLU-1, PLU1, PPP1R98, PUT1, RBBP2H1A
Species	Human
Gene Type	protein-coding
Description	lysine (K)-specific demethylase 5B
Other Description	RBP2-H1|cancer/testis antigen 31|histone demethylase JARID1B|jumonji, AT rich interactive domain 1B|jumonji/ARID domain-containing protein 1B|lysine-specific demethylase 5B|protein phosphatase 1, regulatory subunit 98|putative DNA/chromatin binding motif|retinoblastoma-binding protein 2 homolog 1|retinoblastoma-binding protein 2, homolog 1A
Swissprots	Q15752 Q9UGL1 Q9Y3Q5 O95811
Accessions	AAQ82849 EAW91432 EAW91433 EAW91434 EAW91435 Q9UGL1 AB015348 BAA34803 AF087481 AAD16061 AJ132440 CAB43532 AJ243706 CAB63108 AK001400 BAG50904 AK022521 BAG51084 AK022553 BAG51090 AK074250 AK122752 BAG53706 AK125746 AL133040 CAB61368 AL133048 CAB61375 AL133072 CAB61395 AL137622 CAB70847 AL833515 BC156049 AAI56050 BC157031 AAI57032 CF593335 XM_011509087 XP_011507389 XM_011509088 XP_011507390 XM_011509089 XP_011507391 XM_011509090 XP_011507392 XM_011509091 XP_011507393 XM_011509092 XP_011507394 NM_006618 NP_006609
Function	Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity). {ECO:0000250|UniProtKB:Q80Y84, ECO:0000269|PubMed:12657635, ECO:0000269|PubMed:16645588, ECO:0000269|PubMed:17320161, ECO:0000269|PubMed:17363312}.
Subcellular Location	Nucleus {ECO:0000255|PROSITE- ProRule:PRU00355, ECO:0000255|PROSITE-ProRule:PRU00537, ECO:0000269|PubMed:10336460, ECO:0000269|PubMed:12237901}.
Tissue Specificity	Ubiquitously expressed, with highest levels in testis. Down-regulated in melanoma and glioblastoma. Up-regulated in breast cancer (at protein level). {ECO:0000269|PubMed:10336460, ECO:0000269|PubMed:10616211, ECO:0000269|PubMed:10878660, ECO:0000269|PubMed:12237901, ECO:0000269|PubMed:15803180}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human KDM5B / PLU1 / Jarid1B protein fragment - ab198112 from Abcam Category Protein Prices $1,250.00 Sizes 20 µg Source Baculovirus infected sf9 cells Species Human

Human KDM5B / PLU1 / Jarid1B protein fragment - ab153122 from Abcam Category Protein Source Wheat germ Species Human

Mouse KDM5B / PLU1 / Jarid1B protein fragment - ab198142 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Mouse

KDM5B / JARID1B Antibody Blocking Peptide - LS-E3311 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Lysine (K)-specific Demethylase 5B/KDM5B/JARID1B Protein - H00010765-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

JARID1B-Antibody-N-term-Blocking-Peptide - BP14476a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RBBP2H1 / JARID1B - H00010765-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RBBP2H1 / JARID1B - H00010765-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Recombinant JARID1B / KDM5B protein - 31432 from ActiveMotif Category Protein Prices $395.00, $3,800.00 Sizes 20 μg, 1 mg Source Sf9 cells Species Human

Recombinant Human KDM5B, FLAG-tagged - KDM5B-44H from Creative Biomart Category Protein Source Sf9 insect cells Species Human

Recombinant Human KDM5B - KDM5B-752H from Creative Biomart Category Protein Source Mammalian Cells Species Human

KDM5B protein-GST fusion - 010-001-S36 from Rockland Immunochemicals Inc Category Protein Prices $499.00 Sizes 50 µg Species Mouse

KDM5B protein-GST fusion - 010-001-S36S from Rockland Immunochemicals Inc Category Protein Prices $265.00 Sizes 20 µg Species Mouse

Recombinant Human Lysine-specific demethylase 5B(KDM5B) ,partial - CSB-YP883380HU CSB-EP883380HU CSB-BP883380HU CSB-MP883380HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

KDM5B Protein - abx163930 from Abbexa Category Protein Species Human

Lysine (K)-specific Demethylase 5B/KDM5B/JARID1B Recombinant Protein Antigen - NBP1-84352PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

KDM5B Peptide, Human - M34GP08051H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant JARID1B / KDM5B (2-751) protein - 31518 from ActiveMotif Category Protein Prices $395.00 Sizes 20 µg Source Baculovirus Species Human

Lysine (K)-specific Demethylase 5B/KDM5B/JARID1B Recombinant Protein Antigen - NBP2-58615PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Lysine (K)-specific Demethylase 5B/KDM5B/JARID1B Recombinant Protein Antigen - NBP2-52969PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Source E. coli Species Human

Lysine-specific demethylase 5B (KDM5B), partial, Recombinant Protein - MBS1426308 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Search more