| Gene Symbol |
KDM5B
|
| Entrez Gene |
10765
|
| Alt Symbol |
CT31, JARID1B, PLU-1, PLU1, PPP1R98, PUT1, RBBP2H1A
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
lysine (K)-specific demethylase 5B
|
| Other Description |
RBP2-H1|cancer/testis antigen 31|histone demethylase JARID1B|jumonji, AT rich interactive domain 1B|jumonji/ARID domain-containing protein 1B|lysine-specific demethylase 5B|protein phosphatase 1, regulatory subunit 98|putative DNA/chromatin binding motif|retinoblastoma-binding protein 2 homolog 1|retinoblastoma-binding protein 2, homolog 1A
|
| Swissprots |
Q15752 Q9UGL1 Q9Y3Q5 O95811
|
| Accessions |
AAQ82849 EAW91432 EAW91433 EAW91434 EAW91435 Q9UGL1 AB015348 BAA34803 AF087481 AAD16061 AJ132440 CAB43532 AJ243706 CAB63108 AK001400 BAG50904 AK022521 BAG51084 AK022553 BAG51090 AK074250 AK122752 BAG53706 AK125746 AL133040 CAB61368 AL133048 CAB61375 AL133072 CAB61395 AL137622 CAB70847 AL833515 BC156049 AAI56050 BC157031 AAI57032 CF593335 XM_011509087 XP_011507389 XM_011509088 XP_011507390 XM_011509089 XP_011507391 XM_011509090 XP_011507392 XM_011509091 XP_011507393 XM_011509092 XP_011507394 NM_006618 NP_006609
|
| Function |
Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity). {ECO:0000250|UniProtKB:Q80Y84, ECO:0000269|PubMed:12657635, ECO:0000269|PubMed:16645588, ECO:0000269|PubMed:17320161, ECO:0000269|PubMed:17363312}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00355, ECO:0000255|PROSITE-ProRule:PRU00537, ECO:0000269|PubMed:10336460, ECO:0000269|PubMed:12237901}.
|
| Tissue Specificity |
Ubiquitously expressed, with highest levels in testis. Down-regulated in melanoma and glioblastoma. Up-regulated in breast cancer (at protein level). {ECO:0000269|PubMed:10336460, ECO:0000269|PubMed:10616211, ECO:0000269|PubMed:10878660, ECO:0000269|PubMed:12237901, ECO:0000269|PubMed:15803180}.
|
