| Gene Symbol |
UPF2
|
| Entrez Gene |
26019
|
| Alt Symbol |
HUPF2, RENT2, smg-3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
UPF2 regulator of nonsense transcripts homolog (yeast)
|
| Other Description |
nonsense mRNA reducing factor 2|regulator of nonsense transcripts 2|smg-3 homolog, nonsense mediated mRNA decay factor|up-frameshift suppressor 2 homolog|yeast Upf2p homolog
|
| Swissprots |
Q5W0J4 Q14BM1 Q8N8U1 Q9P2D9 A6NLJ5 Q9HAU5 Q9Y4M9 D3DRS0 Q9NWL1 Q9H1J2
|
| Accessions |
CCO13846 EAW86328 EAW86329 EAW86330 EAW86331 EAW86332 EAW86333 Q9HAU5 AB037829 BAA92646 AF301013 AAG33225 AF318574 AAG60689 AK000764 BAA91369 AK074375 BAB85064 AK096191 BAC04721 AK124930 AK295209 BAG58205 AK310925 AL080198 CAB45771 AW444636 AY013249 AAG48509 BC054011 BC090919 AAH90919 BC114964 AAI14965 BC115737 AAI15738 BX647325 DA188353 DB065422 XM_011519447 XP_011517749 XM_011519448 XP_011517750 XM_011519449 XP_011517751 XR_930489 NM_015542 NP_056357 NM_080599 NP_542166
|
| Function |
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Recruited by UPF3B associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3B stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA. {ECO:0000269|PubMed:11163187, ECO:0000269|PubMed:16209946, ECO:0000269|PubMed:18066079}.
|
| Subcellular Location |
Cytoplasm, perinuclear region {ECO:0000269|PubMed:11073994, ECO:0000269|PubMed:11113196, ECO:0000269|PubMed:11163187}.
|
| Tissue Specificity |
Ubiquitous. {ECO:0000269|PubMed:11073994}.
|
| Top Pathways |
RNA transport, mRNA surveillance pathway
|