UPF2

Gene Symbol	UPF2
Entrez Gene	26019
Alt Symbol	HUPF2, RENT2, smg-3
Species	Human
Gene Type	protein-coding
Description	UPF2 regulator of nonsense transcripts homolog (yeast)
Other Description	nonsense mRNA reducing factor 2|regulator of nonsense transcripts 2|smg-3 homolog, nonsense mediated mRNA decay factor|up-frameshift suppressor 2 homolog|yeast Upf2p homolog
Swissprots	Q5W0J4 Q14BM1 Q8N8U1 Q9P2D9 A6NLJ5 Q9HAU5 Q9Y4M9 D3DRS0 Q9NWL1 Q9H1J2
Accessions	CCO13846 EAW86328 EAW86329 EAW86330 EAW86331 EAW86332 EAW86333 Q9HAU5 AB037829 BAA92646 AF301013 AAG33225 AF318574 AAG60689 AK000764 BAA91369 AK074375 BAB85064 AK096191 BAC04721 AK124930 AK295209 BAG58205 AK310925 AL080198 CAB45771 AW444636 AY013249 AAG48509 BC054011 BC090919 AAH90919 BC114964 AAI14965 BC115737 AAI15738 BX647325 DA188353 DB065422 XM_011519447 XP_011517749 XM_011519448 XP_011517750 XM_011519449 XP_011517751 XR_930489 NM_015542 NP_056357 NM_080599 NP_542166
Function	Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Recruited by UPF3B associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3B stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA. {ECO:0000269|PubMed:11163187, ECO:0000269|PubMed:16209946, ECO:0000269|PubMed:18066079}.
Subcellular Location	Cytoplasm, perinuclear region {ECO:0000269|PubMed:11073994, ECO:0000269|PubMed:11113196, ECO:0000269|PubMed:11163187}.
Tissue Specificity	Ubiquitous. {ECO:0000269|PubMed:11073994}.
Top Pathways	RNA transport, mRNA surveillance pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human hUPF2/RENT2 peptide - ab32332 from Abcam Category Peptide

HUPF2 / UPF2 Antibody Blocking Peptide - LS-E413 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HUPF2 / UPF2 Antibody Blocking Peptide - LS-E14960 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HUPF2 / UPF2 Antibody Blocking Peptide - LS-E26018 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UPF2-Antibody-Center-Blocking-peptide - BP10692c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RENT2/UPF2 blocking peptide - GTX89437-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat, Bovine

hUPF2/RENT2 Peptide - AC21-0846-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

UPF2 Peptide - 46-553P from ProSci Category Peptide

UPF2 fusion protein - ag18516 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

UPF2 fusion protein - ag19766 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human Regulator of nonsense transcripts 2(UPF2) ,partial - CSB-YP867186HU CSB-EP867186HU CSB-BP867186HU CSB-MP867186HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

UPF2 / RENT2 (transcript variant 1) - TP315944 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

RENT2/UPF2, Peptide - MBS426512 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Dog, Bovine

UPF2 Peptide, Human - M34GP17106H from Creative Peptides Category Peptide Source Synthetic. Species Human

Regulator of nonsense transcripts 2 (UPF2), partial, Recombinant Protein - MBS1424730 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

UPF2 Recombinant Protein Antigen - NBP2-57706PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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