| Gene Symbol |
TPR
|
| Entrez Gene |
7175
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
translocated promoter region, nuclear basket protein
|
| Other Description |
NPC-associated intranuclear protein|megator|nuclear pore complex-associated protein TPR|nucleoprotein TPR|translocated promoter region (to activated MET oncogene)|translocated promoter region protein|tumor potentiating region
|
| Swissprots |
Q15624 Q5SWY0 P12270 Q99968
|
| Accessions |
CAA63904 EAW91203 EAW91204 EAW91205 EAW91206 P12270 AA688415 AK023111 AK309473 BC016514 AAH16514 BC025177 AAH25177 BC094764 AAH94764 BC156389 AAI56390 U69668 AAB48030 X63105 CAA44819 X66397 CAA47021 Y00672 CAA68681 XM_011509955 XP_011508257 NM_003292 NP_003283
|
| Function |
Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP
|
| Subcellular Location |
Nucleus. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Nucleus envelope. Nucleus, nuclear pore complex. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Detected as discrete intranuclear foci with IFI204 (By similarity). In interphase, localizes to the nucleoplasmic side of the nuclear pore complex (NPC) core structure, forming a fibrous structure called the nuclear basket. Detected exclusively to the cytoplasmic margin of NPC (PubMed:7798308). Docking to the inner nucleoplasmic side of the NPC is mediated through binding to nucleoporins. Anchored by NUP153 to the NPC. The assembly of the NPC is a stepwise process in which Trp-containing peripheral structures assemble after other components, including p62. Detected as filaments that emanate from the nuclear basket of the NPC and extend to the nucleolus to delineate a chromatin-free network extending from the nucle
|
| Tissue Specificity |
Expressed in esophagus, ovary, liver, skin, smooth muscles, cerebrum and fetal cerebellum (at protein level). Highest in testis, lung, thymus, spleen and brain, lower levels in heart, liver and kidney. {ECO:0000269|PubMed:12424524, ECO:0000269|PubMed:9024684}.
|
| Top Pathways |
Thyroid cancer, RNA transport
|