TPR

Gene Symbol	TPR
Entrez Gene	7175
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	translocated promoter region, nuclear basket protein
Other Description	NPC-associated intranuclear protein|megator|nuclear pore complex-associated protein TPR|nucleoprotein TPR|translocated promoter region (to activated MET oncogene)|translocated promoter region protein|tumor potentiating region
Swissprots	Q15624 Q5SWY0 P12270 Q99968
Accessions	CAA63904 EAW91203 EAW91204 EAW91205 EAW91206 P12270 AA688415 AK023111 AK309473 BC016514 AAH16514 BC025177 AAH25177 BC094764 AAH94764 BC156389 AAI56390 U69668 AAB48030 X63105 CAA44819 X66397 CAA47021 Y00672 CAA68681 XM_011509955 XP_011508257 NM_003292 NP_003283
Function	Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP
Subcellular Location	Nucleus. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Nucleus envelope. Nucleus, nuclear pore complex. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Detected as discrete intranuclear foci with IFI204 (By similarity). In interphase, localizes to the nucleoplasmic side of the nuclear pore complex (NPC) core structure, forming a fibrous structure called the nuclear basket. Detected exclusively to the cytoplasmic margin of NPC (PubMed:7798308). Docking to the inner nucleoplasmic side of the NPC is mediated through binding to nucleoporins. Anchored by NUP153 to the NPC. The assembly of the NPC is a stepwise process in which Trp-containing peripheral structures assemble after other components, including p62. Detected as filaments that emanate from the nuclear basket of the NPC and extend to the nucleolus to delineate a chromatin-free network extending from the nucle
Tissue Specificity	Expressed in esophagus, ovary, liver, skin, smooth muscles, cerebrum and fetal cerebellum (at protein level). Highest in testis, lung, thymus, spleen and brain, lower levels in heart, liver and kidney. {ECO:0000269|PubMed:12424524, ECO:0000269|PubMed:9024684}.
Top Pathways	Thyroid cancer, RNA transport

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

TPR (H-12) - sc-271317 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

TPR (E-20) - sc-34362 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

TPR (H-300) - sc-67116 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

TPR (C-20) - sc-34363 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

TPR (H-8) - sc-271565 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

TPR (3B9) - sc-101294 from Santa Cruz Biotechnology Prices $295.00 Sizes 100 µg/ml Host Mouse Clonality Monoclonal

Anti-TPR antibody - ab58344 from Abcam Prices $385.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-TPR antibody - ab84516 from Abcam Prices $378.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-TPR antibody - ab70610 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-TPR antibody - ab59679 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-TPR antibody [EPR8982] - ab170940 from Abcam Prices $379.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR8982

Anti-TPR antibody - N-terminal - ab200151 from Abcam Host Rabbit Clonality Polyclonal

Anti-TPR Antibody (clone 1A8) - LS-C133494 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 1A8

Anti-TPR Antibody (C-Terminus) - LS-C286369 from LifeSpan Bioscience Prices $415.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-TPR Antibody - LS-C48703 from LifeSpan Bioscience Prices $410.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-TPR Antibody (aa600-650) - LS-C90639 from LifeSpan Bioscience Prices $545.00 Sizes 20 µg Host Rabbit Clonality Polyclonal

Anti-TPR Antibody (aa1650-1700) - LS-C90640 from LifeSpan Bioscience Prices $545.00 Sizes 20 µg Host Rabbit Clonality Polyclonal

Anti-TPR Antibody (aa2275-2325) - LS-C90641 from LifeSpan Bioscience Prices $545.00 Sizes 20 µg Host Rabbit Clonality Polyclonal

Anti-TPR Antibody (C-Terminus) - LS-C90642 from LifeSpan Bioscience Prices $545.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-TPR Antibody (C-Terminus) - LS-C145072 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-TPR Antibody (aa600-650) - LS-C286025 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-TPR Antibody (aa1650-1700) - LS-C287675 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-TPR Antibody (aa2275-2325) - LS-C287678 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-TPR Antibody (aa1-99, Azide-free) - LS-C328916 from LifeSpan Bioscience Host Mouse Clonality Monoclonal

Anti-TPR Antibody (aa2034-2083) - LS-C135923 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

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