| Gene Symbol | USP21 |
|---|---|
| Entrez Gene | 27005 |
| Alt Symbol | USP16, USP23 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ubiquitin specific peptidase 21 |
| Other Description | NEDD8-specific protease|deubiquitinating enzyme 21|ubiquitin carboxyl-terminal hydrolase 21|ubiquitin specific protease 21|ubiquitin thioesterase 21|ubiquitin thiolesterase 21|ubiquitin-specific processing protease 21|ubiquitin-specific protease 16|ubiquitin-specific-processing protease 21 |
| Swissprots | Q9NYN4 Q5BKT5 Q9HBS2 Q9BTV1 Q5VTW9 Q59H60 Q9UK80 Q5VTX0 |
| Accessions | CCQ43414 EAW52642 EAW52643 EAW52644 EAW52645 Q9UK80 AB208899 BAD92136 AF177758 AAD54321 AF217979 AAG17222 AF233442 AAF61308 AI038040 AK292319 BAF85008 AK310326 AL157417 CAB75649 BC003130 AAH03130 BC090946 AAH90946 BC136291 AAI36292 BI463191 BI755746 BM742944 N76159 T77123 XM_006711274 XP_006711337 XM_011509412 XP_011507714 XM_011509413 XP_011507715 XM_011509414 XP_011507716 NM_001014443 NP_001014443 NM_012475 NP_036607 |
| Function | Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination (By similarity). Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates. {ECO:0000250, ECO:0000269|PubMed:10799498}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:21888622}. Nucleus {ECO:0000269|PubMed:21888622}. |
| Tissue Specificity | Highly expressed in heart, pancreas and skeletal muscle. Also expressed in brain, placenta, liver and kidney, and at very low level in lung. {ECO:0000269|PubMed:10799498}. |