| Gene Symbol |
DDN
|
| Entrez Gene |
23109
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
dendrin
|
| Other Description |
-
|
| Swissprots |
O94850
|
| Accessions |
EAW58031 O94850 AB018292 BAA34469 BC039264 BC136398 AAI36399 BC136399 AAI36400 XM_011538055 XP_011536357 NM_015086 NP_055901
|
| Function |
Promotes apoptosis of kidney glomerular podocytes. Podocytes are highly specialized cells essential to the ultrafiltration of blood, resulting in the extraction of urine and the retention of protein (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell projection, dendritic spine membrane; Peripheral membrane protein. Cytoplasm. Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Perikaryon {ECO:0000250}. Nucleus {ECO:0000250}. Note=Enriched at the cytoplasmic insertion of the slit diaphragm into the foot process of podocytes and associated with polyribosomes in dendrites. {ECO:0000250}.
|
| Tissue Specificity |
Specifically expressed in brain and kidney. Expressed in kidney glomerular capillary loops (at protein level). {ECO:0000269|PubMed:17251388, ECO:0000269|PubMed:18356187}.
|