Gene Symbol | DDN |
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Entrez Gene | 23109 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | dendrin |
Other Description | - |
Swissprots | O94850 |
Accessions | EAW58031 O94850 AB018292 BAA34469 BC039264 BC136398 AAI36399 BC136399 AAI36400 XM_011538055 XP_011536357 NM_015086 NP_055901 |
Function | Promotes apoptosis of kidney glomerular podocytes. Podocytes are highly specialized cells essential to the ultrafiltration of blood, resulting in the extraction of urine and the retention of protein (By similarity). {ECO:0000250}. |
Subcellular Location | Cell projection, dendritic spine membrane; Peripheral membrane protein. Cytoplasm. Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Perikaryon {ECO:0000250}. Nucleus {ECO:0000250}. Note=Enriched at the cytoplasmic insertion of the slit diaphragm into the foot process of podocytes and associated with polyribosomes in dendrites. {ECO:0000250}. |
Tissue Specificity | Specifically expressed in brain and kidney. Expressed in kidney glomerular capillary loops (at protein level). {ECO:0000269|PubMed:17251388, ECO:0000269|PubMed:18356187}. |
dendrin CRISPR/Cas9 KO Plasmid (h) - sc-404856 from Santa Cruz Biotechnology
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dendrin HDR Plasmid (h) - sc-404856-HDR from Santa Cruz Biotechnology
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dendrin Double Nickase Plasmid (h) - sc-404856-NIC from Santa Cruz Biotechnology
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dendrin Double Nickase Plasmid (h2) - sc-404856-NIC-2 from Santa Cruz Biotechnology
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dendrin CRISPR Activation Plasmid (h) - sc-404856-ACT from Santa Cruz Biotechnology
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dendrin CRISPR Activation Plasmid (h2) - sc-404856-ACT-2 from Santa Cruz Biotechnology
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dendrin Lentiviral Activation Particles (h) - sc-404856-LAC from Santa Cruz Biotechnology
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dendrin Lentiviral Activation Particles (h2) - sc-404856-LAC-2 from Santa Cruz Biotechnology
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dendrin siRNA (h) - sc-96231 from Santa Cruz Biotechnology
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dendrin shRNA Plasmid (h) - sc-96231-SH from Santa Cruz Biotechnology
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dendrin shRNA (h) Lentiviral Particles - sc-96231-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU007281 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7028 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7028 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09853 from Sigma-Aldrich
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DDN siRNA (Human) - CRH8004 from Cohesion Biosciences
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DDN - MBS8217317 from MyBioSource
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shRNA set against Human DDN (NM_015086.1) - SHH275689 from Creative biogene
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shRNA set against Human DDN(NM_015086.1) - SHG226203 from Creative biogene
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Human DDN siRNA - orb268506 from Biorbyt
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DDN shRNA Plasmid (Human) - CHH8004 from Cohesion Biosciences
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DDN miRNA 3'UTR clone - MiUTR1H-02711 from Creative biogene
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