HTRA3

Gene Symbol HTRA3
Entrez Gene 94031
Alt Symbol Prsp, Tasp
Species Human
Gene Type protein-coding
Description HtrA serine peptidase 3
Other Description high-temperature requirement factor A3|pregnancy-related serine protease|probable serine protease HTRA3|serine protease HTRA3
Swissprots P83110 Q7Z7A2
Accessions EAW82345 EAW82346 P83110 AL547377 AW072765 AY040094 AAK71475 AY280665 AAP42282 AY280666 AAP42283 BC034390 AAH34390 BC035717 AAH35717 DN996853 DQ891188 ABM82114 DQ894371 ABM85297 XM_011513596 XP_011511898 NM_001297559 NP_001284488 NM_053044 NP_444272
Function Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans (By similarity). May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization. {ECO:0000250}.
Subcellular Location Secreted {ECO:0000269|PubMed:21321049}. Note=Secretion increased during decidualization of endometrial stromal cells.
Tissue Specificity Widely expressed, with highest levels in both adult and fetal heart, ovary, uterus placenta, and bladder. In the endometrium, expressed in epithelial glands and the stroma. Also present in leukocytes. Isoform 1 is predominant in heart and skeletal muscle, whereas isoform 2 is predominant in placenta and kidney. {ECO:0000269|PubMed:12513693, ECO:0000269|PubMed:16650464, ECO:0000269|PubMed:21321049}.

HtrA3 (N-12) - sc-79531 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
HtrA3 (N-12): sc-79531. Western blot analysis of HtrA3 expression in 293T whole cell lysate.

HtrA3 (S-13) - sc-79532 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
HtrA3 (S-13): sc-79532. Western blot analysis of HtrA3 expression in 293T whole cell lysate.

HtrA3 (Z-25) - sc-130781 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-HtrA3 antibody - ab38608 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-HtrA3 antibody (ab38608) at 1/100 dilution + Rat testis tissue lysate

Anti-HtrA3 antibody - ab198722 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue labeling HtrA3 with ab198722 at 1/45 dilution.

Anti-HtrA3 antibody - ab116644 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-HtrA3 antibody (ab116644) at 1/100 dilution + Mouse heart tissue lysate at 35 µg

Anti-HtrA3 antibody - ab65910 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-HtrA3 antibody (ab65910) at 1/1000 dilutionLane 1 : Molecular weight markersLane 2 : HEK-293 with TNF alpha in complete mediumLane 3 : HFL-1 in Serum free complete medium.Lane 4 : HFL-1 in Complete Medium with TPA treatmentLane 5 : HFL-1 in Complete Medium with IL 1-Beta treatmentLane 6 : HFL-1 in Complete Medium with Beta-estradiol treatmentLane 7 : HFL-1 in Complete Medium with Progesterone treatment

Anti-HtrA3 antibody - ab65912 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-HtrA3 antibody (ab65912) at 1/1000 dilutionLane 1 : Tissue lysate prepared from rat brain Lane 2 : Tissue lysate prepared from rat heart Lane 3 : Tissue lysate prepared from rat kidney Lane 4 : Tissue lysate prepared from rat liver Lane 5 : Tissue lysate prepared from rat lung Lane 6 : Tissue lysate prepared from rat ovary Lane 7 : Tissue lysate prepared from rat prostate

Anti-HtrA3 antibody - Carboxyterminal end - ab65913 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-HtrA3 antibody - Carboxyterminal end (ab65913) at 1/1000 dilutionLane 1 : Tissue lysate prepared from rat brainLane 2 : Tissue lysate prepared from rat heartLane 3 : Tissue lysate prepared from rat kidneyLane 4 : Tissue lysate prepared from rat liverLane 5 : Tissue lysate prepared from mouse brainLane 6 : Tissue lysate prepared from mouse heartLane 7 : Tissue lysate prepared from human heart

Anti-HtrA3 antibody - Catalytic domain - ab65911 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-HtrA3 antibody - Catalytic domain (ab65911) at 1/1000 dilutionLane 1 : SW 620 with SFLane 2 : SW 620 with TPALane 3 : SW 620 with IL 1-AlphaLane 4 : SW 620 with IL 1-BetaLane 5 : Molecular weight markers

Anti-HTRA3 Antibody - LS-C125736 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-HTRA3 Antibody (aa188-237) - LS-C151754 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
HTRA3 antibody Western Blot of Fetal Brain.

Anti-HTRA3 Antibody - LS-C155475 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Sample (30 ug of whole cell lysate) A: 293T 10% SDS PAGE HTRA3 antibody diluted at 1:1000

Anti-HTRA3 Antibody (aa112-144) - LS-C98693 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human placenta tissue reacted with HtrA3 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-HTRA3 Antibody (aa250-300) IHC-plus™ - LS-B2043 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-HTRA3 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2043 concentration 10 ug/ml.

HtrA3 Antibody - NB600-1151 from Novus Biologicals

Prices $99.00, $229.00
Sizes 25 µg, 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: HtrA3 Antibody [NB600-1151] - Western bot analysis of HtrA3 in rat heart lysate using NB600-1151 at 2 ug/ml.

HtrA3 Antibody - NBP1-87211 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

HtrA3 Antibody - NBP2-16903 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: HtrA3 Antibody [NBP2-16903] - Sample (30 ug of whole cell lysate) A: 293T 10% SDS PAGE gel, diluted at 1:1000.

HtrA3 Antibody - NBP2-16902 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

HtrA3 Antibody (1F2) - H00094031-M03 from Novus Biologicals

Prices $349.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1F2

HtrA3 Antibody - NBP1-39951 from Novus Biologicals

Prices $399.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western Blot: HtrA3 Antibody [NBP1-39951] - Western blot analysis of HtrA3 in rat heart lysate using antibody at 2 ug/ml.

Anti-HTRA3 antibody produced in rabbit - SAB2700549 from Sigma-Aldrich

Prices $326.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-HTRA3: <B>Cat. No. SAB2700549</B>: Western Blot analysis of HTRA3 in extracts from <B>Lanes</B><BR/>A. 293T using <B>Cat. No. SAB2700549</B> at a 1:1000 dilution.

Anti-HTRA3 antibody produced in rabbit - HPA021187 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-HTRA3: <B>Cat. No. HPA021187</B>: Immunohistochemical staining of human kidney shows moderate cytoplasmic positivity in cells in tubules.

Anti-HTRA3 antibody produced in rabbit - SAB2700552 from Sigma-Aldrich

Prices $326.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-HTRA3: <B>Cat. No. SAB2700552</B>: Western Blot analysis of HTRA3 in extracts from <B>Lanes</B><BR/>A. U87-MG <BR/>B. SK-N-SH using <B>Cat. No. SAB2700552</B> at a 1:1000 dilution.

HTRA3 antibody - middle region (ARP64570_P050) - ARP64570_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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