HTRA3

Gene Symbol HTRA3
Entrez Gene 94031
Alt Symbol Prsp, Tasp
Species Human
Gene Type protein-coding
Description HtrA serine peptidase 3
Other Description high-temperature requirement factor A3|pregnancy-related serine protease|probable serine protease HTRA3|serine protease HTRA3
Swissprots P83110 Q7Z7A2
Accessions EAW82345 EAW82346 P83110 AL547377 AW072765 AY040094 AAK71475 AY280665 AAP42282 AY280666 AAP42283 BC034390 AAH34390 BC035717 AAH35717 DN996853 DQ891188 ABM82114 DQ894371 ABM85297 XM_011513596 XP_011511898 NM_001297559 NP_001284488 NM_053044 NP_444272
Function Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans (By similarity). May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization. {ECO:0000250}.
Subcellular Location Secreted {ECO:0000269|PubMed:21321049}. Note=Secretion increased during decidualization of endometrial stromal cells.
Tissue Specificity Widely expressed, with highest levels in both adult and fetal heart, ovary, uterus placenta, and bladder. In the endometrium, expressed in epithelial glands and the stroma. Also present in leukocytes. Isoform 1 is predominant in heart and skeletal muscle, whereas isoform 2 is predominant in placenta and kidney. {ECO:0000269|PubMed:12513693, ECO:0000269|PubMed:16650464, ECO:0000269|PubMed:21321049}.

HtrA3 CRISPR/Cas9 KO Plasmid (h) - sc-413989 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HtrA3 HDR Plasmid (h) - sc-413989-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HtrA3 Double Nickase Plasmid (h) - sc-413989-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HtrA3 Double Nickase Plasmid (h2) - sc-413989-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HtrA3 CRISPR Activation Plasmid (h) - sc-413989-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HtrA3 CRISPR Activation Plasmid (h2) - sc-413989-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HtrA3 Lentiviral Activation Particles (h) - sc-413989-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HtrA3 Lentiviral Activation Particles (h2) - sc-413989-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HtrA3 siRNA (h) - sc-75313 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HtrA3 shRNA Plasmid (h) - sc-75313-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HtrA3 shRNA (h) Lentiviral Particles - sc-75313-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU008431 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN10403 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10403 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR07648 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr07648

HTRA3 siRNA (Human) - CRJ4240 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

HTRA3 - MBS827274 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human HTRA3 (NM_053044.3) - SHH316065 from Creative biogene

Category siRNA
Species Reactivities Human

HTRA3 shRNA Plasmid (Human) - CHJ4240 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

HTRA3 miRNA 3'UTR clone - MiUTR3H-10226 from Creative biogene

Species Reactivities Human
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