| Gene Symbol |
ATL3
|
| Entrez Gene |
25923
|
| Alt Symbol |
HSN1F
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
atlastin GTPase 3
|
| Other Description |
atlastin-3
|
| Swissprots |
Q8N7W5 Q6DD88 Q9UFL1 Q9H8Q5
|
| Accessions |
EAW74161 EAW74162 EAW74163 Q6DD88 AK023383 BAB14552 AK090822 AK094227 AK097588 BAC05111 AK301910 BAG63336 AL117600 CAB56010 BC077727 AAH77727 BE710391 BI829120 BX642720 BX648468 CR936784 DB034045 DC394729 XM_006718493 XP_006718556 XM_006718494 XP_006718557 XM_011544902 XP_011543204 NM_001290048 NP_001276977 NM_015459 NP_056274
|
| Function |
GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. {ECO:0000269|PubMed:18270207, ECO:0000269|PubMed:19665976}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:18270207, ECO:0000269|PubMed:24459106}; Multi- pass membrane protein {ECO:0000269|PubMed:18270207, ECO:0000269|PubMed:24459106}. Note=Localizes to endoplasmic reticulum tubules and accumulates in punctuate structures corresponding to 3-way junctions, which represent crossing-points at which the tubules build a polygonal network.
|
| Tissue Specificity |
Expressed in the central nervous system and in dorsal root ganglia neurons. Expressed in peripheral tissues (at protein level). {ECO:0000269|PubMed:18270207, ECO:0000269|PubMed:24459106}.
|
![Western Blot: Atlastin-3 Overexpression Lysate (Adult Normal) [NBP2-07170] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Atlastin-3.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8663_Atlastin-3%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-07170-img0001.jpg)