Gene Symbol | ATL3 |
---|---|
Entrez Gene | 25923 |
Alt Symbol | HSN1F |
Species | Human |
Gene Type | protein-coding |
Description | atlastin GTPase 3 |
Other Description | atlastin-3 |
Swissprots | Q8N7W5 Q6DD88 Q9UFL1 Q9H8Q5 |
Accessions | EAW74161 EAW74162 EAW74163 Q6DD88 AK023383 BAB14552 AK090822 AK094227 AK097588 BAC05111 AK301910 BAG63336 AL117600 CAB56010 BC077727 AAH77727 BE710391 BI829120 BX642720 BX648468 CR936784 DB034045 DC394729 XM_006718493 XP_006718556 XM_006718494 XP_006718557 XM_011544902 XP_011543204 NM_001290048 NP_001276977 NM_015459 NP_056274 |
Function | GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. {ECO:0000269|PubMed:18270207, ECO:0000269|PubMed:19665976}. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:18270207, ECO:0000269|PubMed:24459106}; Multi- pass membrane protein {ECO:0000269|PubMed:18270207, ECO:0000269|PubMed:24459106}. Note=Localizes to endoplasmic reticulum tubules and accumulates in punctuate structures corresponding to 3-way junctions, which represent crossing-points at which the tubules build a polygonal network. |
Tissue Specificity | Expressed in the central nervous system and in dorsal root ganglia neurons. Expressed in peripheral tissues (at protein level). {ECO:0000269|PubMed:18270207, ECO:0000269|PubMed:24459106}. |