ADARB1

Gene Symbol ADARB1
Entrez Gene 104
Alt Symbol ADAR2, DRABA2, DRADA2, RED1
Species Human
Gene Type protein-coding
Description adenosine deaminase, RNA-specific, B1
Other Description RED1 homolog|RNA editase|RNA editing deaminase 1|RNA-editing deaminase 1|RNA-editing enzyme 1|adenosine deaminase, RNA-specific, B1 (RED1 homolog rat)|adenosine deaminase, RNA-specific, B1 (homolog of rat RED1)|double-stranded RNA-specific editase 1|dsRNA adenosine deaminase DRADA2
Swissprots Q8NFA1 O00691 Q4AE77 O00692 Q6P0M9 A6NFK8 O00465 G5E9B4 C9JUP4 C3TTQ2 O00395 Q4AE79 Q8NFD1 A6NJ84 P78563 P78555
Accessions CAB09392 CAB90493 EAX09357 EAX09358 EAX09359 EAX09360 EAX09361 EAX09362 P78563 AB194369 BAE16325 AB194370 BAE16326 AB194371 BAE16327 AB194372 BAE16328 AB194373 BAE16329 AF001042 AAB58300 AF525422 AAM83100 AF533142 AAM97654 AY082339 AAL99252 AY135659 AAN10291 BC030663 BC046198 BC065545 AAH65545 BU726292 FJ169506 ACN49027 U73197 AAB18134 U76420 AAC51240 U76421 AAC51241 U76422 AAC51242 U82120 AAB61686 U82121 AAB61687 X99227 CAA67611 X99383 CAA67762 XM_006723954 XP_006724017 XM_006723956 XP_006724019 XM_011529424 XP_011527726 XM_011529425 XP_011527727 XM_011529426 XP_011527728 XM_011529427 XP_011527729 XM_011529428 XP_011527730 XM_011529429 XP_011527731 XM_011529430 XP_011527732 XM_011529431 XP_011527733 XM_011529432 XP_011527734 NM_001033049 NM_001112 NP_001103 NM_001160230 NP_001153702 NM_015833 NP_056648 NM_015834 NP_056649 NR_027672 NR_027673 NR_027674 NR_073200
Function Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer- associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2 and GRIK2) and serotonin (HTR2C), GABA receptor (GABRA3) and potassium voltage-gated channel (KCNA1)
Subcellular Location Nucleus. Nucleus, nucleolus. Note=Shuttles between nucleoli and the nucleoplasm.
Tissue Specificity Highly expressed in brain and heart and at lower levels in placenta. Fair expression in lung, liver and kidney. Detected in brain, heart, kidney, lung and liver (at protein level). Isoform 5 is high expressed in hippocampus and colon. Isoform 5 is expressed in pediatric astrocytomas and the protein has a decreased RNA-editing activity. The decrease in RNA editing correlates with the grade of malignancy of the tumors, with the high grade tumors showing lower editing is seen. {ECO:0000269|PubMed:18178553, ECO:0000269|PubMed:19156214, ECO:0000269|PubMed:9149227}.

ADAR2 (1.3.1) - sc-73409 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ADAR2 (1.3.1): sc-73409. Western blot analysis of ADAR2 expression in non-transfected: sc-117752 (A) and human ADAR2 transfected: sc-117039 (B) 293T whole cell lysates.

ADAR2 (A-3) - sc-393068 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ADAR2 (A-3): sc-393068. Western blot analysis of ADAR2 expression in non-transfected 293T: sc-117752 (A), human ADAR2 transfected 293T: sc-117039 (B) and HL-60 (C) whole cell lysates.

ADAR2 (A-5) - sc-393272 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ADAR2 (A-5): sc-393272. Western blot analysis of ADAR2 expression in non-transfected: sc-117752 (A) and human ADAR2 transfected: sc-117039 (B) 293T whole cell lysates.

ADAR2 (C-2) - sc-398122 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ADAR2 (C-2): sc-398122. Western blot analysis of ADAR2 expression in non-transfected: sc-117752 (A) and human ADAR2 transfected: sc-117039 (B) 293T whole cell lysates.

ADAR2 (H-90) - sc-33180 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
ADAR2 (H-90): sc-33180. Western blot analysis of ADAR2 expression in non-transfected: sc-117752 (A) and human ADAR2 transfected: sc-117039 (B) 293T whole cell lysates.

ADAR2 (C-15) - sc-10012 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ADAR2 (C-15): sc-10012. Western blot analysis of ADAR2 expression in non-transfected: sc-117752 (A) and human ADAR2 transfected: sc-117039 (B) 293T whole cell lysates.

ADAR2 (C-16) - sc-19069 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

ADAR2 (E-20) - sc-10010 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ADAR2 (E-20): sc-10010. Western blot analysis of ADAR2 expression in non-transfected: sc-117752 (A) and human ADAR2 transfected: sc-117039 (B) 293T whole cell lysates.

ADAR2 (F-9) - sc-390995 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ADAR2 (F-9): sc-390995. Western blot analysis of ADAR2 expression in non-transfected: sc-117752 (A) and human ADAR2 transfected: sc-117039 (B) 293T whole cell lysates.

ADAR2 (L-15) - sc-10011 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

ADAR2 (K-20) - sc-19068 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ADAR2 (K-20): sc-19068. Western blot analysis of ADAR2 expression in non-transfected: sc-117752 (A) and human ADAR2 transfected: sc-117039 (B) 293T whole cell lysates.

Anti-RED1 antibody - ab64830 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-RED1 antibody (ab64830) at 1/500 dilutionLane 1 : HepG2 cell extract (5-30 µg total protein)Lane 2 : HepG2 cell extract (5-30 µg total protein) ) with 5-10 µg of the immunising peptide

Anti-RED1 antibody - ab89436 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-RED1 antibody (ab89436) at 1 µg/ml + Human kidney lysate at 50 µgdeveloped using the ECL technique

Anti-RED1 antibody - ab183616 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-RED1 antibody (ab183616) at 1/1000 dilution + NT2D1 whole cell lysate at 30 µg

Anti-RED1 antibody [2011C3a] - ab76555 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2011C3a
Anti-RED1 antibody [2011C3a] (ab76555) + immunizing recombinant protein fragment

Anti-ADAR2 / ADARB1 Antibody - LS-C306104 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-ADAR2 / ADARB1 Antibody (aa40-89) - LS-C31730 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
A: Marker, B: HepG2 Cell Lysate

Anti-ADAR2 / ADARB1 Antibody (N-Terminus) - LS-C110509 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ADARB1 / RED1 antibody LS-C110509 Western blot of Transfected 293T cell lysate.

Anti-ADAR2 / ADARB1 Antibody (clone 2011C3a) - LS-C342723 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2011C3a
Western blot analysis of immunized recombinant protein, using anti-ADARB1 monoclonal antibody.

Anti-ADAR2 / ADARB1 Antibody (aa481-530) - LS-C118968 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from HepG2 cells, using ADARB1 Antibody. The lane on the right is treated with the synthesized peptide.

Anti-ADAR2 / ADARB1 Antibody - LS-C26569 from LifeSpan Bioscience

Prices $330.00
Sizes 50 µg
Host Sheep
Clonality Polyclonal
Immunofluorescence staining of mouse anterior horns of spinal cord at 6 months, 15 months and 26 months of age. Antibody used at 1:100 dilution and visualized using donkey anti-sheep conjugated to Alexa 555 dye (red color). The blue color is a fluorescent nuclear probe, TOPRO3. (Image modified from original in citation 1)

Anti-ADAR2 / ADARB1 Antibody (Arg510) - LS-C176789 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of ADAR2 (R510) pAb in extracts from A549 cells.

Anti-ADAR2 / ADARB1 Antibody (N-Terminus) - LS-C124997 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-ADAR2 / ADARB1 Antibody (clone 2011C3a) - LS-C184695 from LifeSpan Bioscience

Prices $335.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 2011C3a

RED1 Antibody - NBP1-90240 from Novus Biologicals

Prices $129.00, $419.00
Sizes 25 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: RED1 Antibody [NBP1-90240] - Analysis in human cell line U-251 MG.
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