| Gene Symbol |
ADARB1
|
| Entrez Gene |
104
|
| Alt Symbol |
ADAR2, DRABA2, DRADA2, RED1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
adenosine deaminase, RNA-specific, B1
|
| Other Description |
RED1 homolog|RNA editase|RNA editing deaminase 1|RNA-editing deaminase 1|RNA-editing enzyme 1|adenosine deaminase, RNA-specific, B1 (RED1 homolog rat)|adenosine deaminase, RNA-specific, B1 (homolog of rat RED1)|double-stranded RNA-specific editase 1|dsRNA adenosine deaminase DRADA2
|
| Swissprots |
Q8NFA1 O00691 Q4AE77 O00692 Q6P0M9 A6NFK8 O00465 G5E9B4 C9JUP4 C3TTQ2 O00395 Q4AE79 Q8NFD1 A6NJ84 P78563 P78555
|
| Accessions |
CAB09392 CAB90493 EAX09357 EAX09358 EAX09359 EAX09360 EAX09361 EAX09362 P78563 AB194369 BAE16325 AB194370 BAE16326 AB194371 BAE16327 AB194372 BAE16328 AB194373 BAE16329 AF001042 AAB58300 AF525422 AAM83100 AF533142 AAM97654 AY082339 AAL99252 AY135659 AAN10291 BC030663 BC046198 BC065545 AAH65545 BU726292 FJ169506 ACN49027 U73197 AAB18134 U76420 AAC51240 U76421 AAC51241 U76422 AAC51242 U82120 AAB61686 U82121 AAB61687 X99227 CAA67611 X99383 CAA67762 XM_006723954 XP_006724017 XM_006723956 XP_006724019 XM_011529424 XP_011527726 XM_011529425 XP_011527727 XM_011529426 XP_011527728 XM_011529427 XP_011527729 XM_011529428 XP_011527730 XM_011529429 XP_011527731 XM_011529430 XP_011527732 XM_011529431 XP_011527733 XM_011529432 XP_011527734 NM_001033049 NM_001112 NP_001103 NM_001160230 NP_001153702 NM_015833 NP_056648 NM_015834 NP_056649 NR_027672 NR_027673 NR_027674 NR_073200
|
| Function |
Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer- associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2 and GRIK2) and serotonin (HTR2C), GABA receptor (GABRA3) and potassium voltage-gated channel (KCNA1)
|
| Subcellular Location |
Nucleus. Nucleus, nucleolus. Note=Shuttles between nucleoli and the nucleoplasm.
|
| Tissue Specificity |
Highly expressed in brain and heart and at lower levels in placenta. Fair expression in lung, liver and kidney. Detected in brain, heart, kidney, lung and liver (at protein level). Isoform 5 is high expressed in hippocampus and colon. Isoform 5 is expressed in pediatric astrocytomas and the protein has a decreased RNA-editing activity. The decrease in RNA editing correlates with the grade of malignancy of the tumors, with the high grade tumors showing lower editing is seen. {ECO:0000269|PubMed:18178553, ECO:0000269|PubMed:19156214, ECO:0000269|PubMed:9149227}.
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