ADARB1

Gene Symbol	ADARB1
Entrez Gene	104
Alt Symbol	ADAR2, DRABA2, DRADA2, RED1
Species	Human
Gene Type	protein-coding
Description	adenosine deaminase, RNA-specific, B1
Other Description	RED1 homolog|RNA editase|RNA editing deaminase 1|RNA-editing deaminase 1|RNA-editing enzyme 1|adenosine deaminase, RNA-specific, B1 (RED1 homolog rat)|adenosine deaminase, RNA-specific, B1 (homolog of rat RED1)|double-stranded RNA-specific editase 1|dsRNA adenosine deaminase DRADA2
Swissprots	Q8NFA1 O00691 Q4AE77 O00692 Q6P0M9 A6NFK8 O00465 G5E9B4 C9JUP4 C3TTQ2 O00395 Q4AE79 Q8NFD1 A6NJ84 P78563 P78555
Accessions	CAB09392 CAB90493 EAX09357 EAX09358 EAX09359 EAX09360 EAX09361 EAX09362 P78563 AB194369 BAE16325 AB194370 BAE16326 AB194371 BAE16327 AB194372 BAE16328 AB194373 BAE16329 AF001042 AAB58300 AF525422 AAM83100 AF533142 AAM97654 AY082339 AAL99252 AY135659 AAN10291 BC030663 BC046198 BC065545 AAH65545 BU726292 FJ169506 ACN49027 U73197 AAB18134 U76420 AAC51240 U76421 AAC51241 U76422 AAC51242 U82120 AAB61686 U82121 AAB61687 X99227 CAA67611 X99383 CAA67762 XM_006723954 XP_006724017 XM_006723956 XP_006724019 XM_011529424 XP_011527726 XM_011529425 XP_011527727 XM_011529426 XP_011527728 XM_011529427 XP_011527729 XM_011529428 XP_011527730 XM_011529429 XP_011527731 XM_011529430 XP_011527732 XM_011529431 XP_011527733 XM_011529432 XP_011527734 NM_001033049 NM_001112 NP_001103 NM_001160230 NP_001153702 NM_015833 NP_056648 NM_015834 NP_056649 NR_027672 NR_027673 NR_027674 NR_073200
Function	Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer- associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2 and GRIK2) and serotonin (HTR2C), GABA receptor (GABRA3) and potassium voltage-gated channel (KCNA1)
Subcellular Location	Nucleus. Nucleus, nucleolus. Note=Shuttles between nucleoli and the nucleoplasm.
Tissue Specificity	Highly expressed in brain and heart and at lower levels in placenta. Fair expression in lung, liver and kidney. Detected in brain, heart, kidney, lung and liver (at protein level). Isoform 5 is high expressed in hippocampus and colon. Isoform 5 is expressed in pediatric astrocytomas and the protein has a decreased RNA-editing activity. The decrease in RNA editing correlates with the grade of malignancy of the tumors, with the high grade tumors showing lower editing is seen. {ECO:0000269|PubMed:18178553, ECO:0000269|PubMed:19156214, ECO:0000269|PubMed:9149227}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RED1 full length protein - ab157847 from Abcam Category Protein Source Wheat germ Species Human

Human RED1 protein fragment - ab157848 from Abcam Category Protein Source Wheat germ Species Human

ADAR2 / ADARB1 Antibody Blocking Peptide - LS-E14699 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human RED1 Protein - H00000104-P01 from Novus Biologicals Category Protein Prices $305.00, $445.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human RED1 Protein - H00000104-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

ADARB1 Blocking Peptide - 33R-6800 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

ADARB1 Blocking Peptide - 33R-7645 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

ADAR2 Blocking Peptide - abx062211 from Abbexa Category Peptide Species Human, Mouse, Rat, Chicken, Zebrafish

ADARB1 / ADAR2 - H00000104-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

ADARB1 / ADAR2 - H00000104-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

ADARB1 fusion protein - ag6814 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

ADARB1 fusion protein - Ag17852 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

ADARB1 fusion protein - Ag17743 from Proteintech Group Category Protein Source E. coli -derived, PGEX-4T Species Human

ADAR2 Blocking Peptide - CBP1017 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Chicken, Zebrafish

ADAR2 (R510) Peptide - BS2026P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human Double-stranded RNA-specific editase 1(ADARB1) - CSB-YP001325HU CSB-EP001325HU CSB-BP001325HU CSB-MP001325HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

ADARB1 / ADAR2 (transcript variant 1) - TP309073 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

ADARB1 / ADAR2 (transcript variant 2) - TP312324 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

RED1 Recombinant Protein Antigen - NBP1-90240PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

ADARB1 Peptide, Human - M34GP00275H from Creative Peptides Category Peptide Source Synthetic. Species Human

Double-stranded RNA-specific editase 1 (ADARB1), Recombinant Protein - MBS956472 from MyBioSource Category Protein Prices $1,555.00, $1,555.00, $1,780.00, $1,780.00, $2,670.00, $2,670.00, $3,115.00, $3,115.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

ADARB1 peptide - orb216880 from Biorbyt Category Peptide Species Human, Mouse, Rat, Zebrafish, Cat

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