| Gene Symbol |
USP16
|
| Entrez Gene |
10600
|
| Alt Symbol |
UBP-M, UBPM
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ubiquitin specific peptidase 16
|
| Other Description |
deubiquitinating enzyme 16|ubiquitin carboxyl-terminal hydrolase 16|ubiquitin specific protease 16|ubiquitin thioesterase 16|ubiquitin thiolesterase 16|ubiquitin-processing protease UBP-M|ubiquitin-specific processing protease 16|ubiquitin-specific-processing protease 16
|
| Swissprots |
B4DFV8 Q9H3E6 B3KN13 Q53GP7 Q5VKN8 A8MU43 D3DSD9 B4DY37 Q53HA0 Q8NEL3 Q9Y5T5
|
| Accessions |
CAB90432 EAX09927 EAX09928 EAX09929 Q9Y5T5 AF113219 AAG39290 AF126736 AAD20949 AK023247 BAG51175 AK025104 AK025989 AK090776 AK222681 BAD96401 AK222884 BAD96604 AK294284 BAG57569 AK300771 BAG62436 AK302247 BAG63599 AY333928 AAR13293 BC010375 BC030777 AAH30777 BQ637016 CB960929 DQ892395 ABM83321 DQ895610 ABM86536 W57837 NM_001001992 NP_001001992 NM_001032410 NP_001027582 NM_006447 NP_006438
|
| Function |
Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T- lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B. {ECO:0000255|HAMAP-Rule:MF_03062, ECO:0000269|PubMed:10077596, ECO:0000269|PubMed:17914355}.
|
| Subcellular Location |
Nucleus {ECO:0000305|PubMed:17914355}.
|
| Tissue Specificity |
Present in all the tissues examined including fetal brain, lung, liver, kidney, and adult heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:10077596}.
|