| Gene Symbol |
TRMT5
|
| Entrez Gene |
57570
|
| Alt Symbol |
KIAA1393, TRM5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
tRNA methyltransferase 5
|
| Other Description |
M1G-methyltransferase|TRM5 tRNA methyltransferase 5 homolog|tRNA (guanine(37)-N1)-methyltransferase|tRNA (guanine-N(1)-)-methyltransferase|tRNA [GM37] methyltransferase|tRNA-N1G37 methyltransferase
|
| Swissprots |
B2RN19 Q9P2F4 Q32P41
|
| Accessions |
EAW80792 Q32P41 AB037814 BAA92631 AK293158 BAG56703 BC029638 BC063551 BC108284 AAI08285 BC136606 AAI36607 BC136607 AAI36608 BQ050607 DB448202 DC370229 XM_005267916 XP_005267973 XM_011537017 XP_011535319 NM_020810 NP_065861
|
| Function |
Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.
|
| Subcellular Location |
Mitochondrion matrix {ECO:0000255|HAMAP- Rule:MF_03152}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03152}. Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03152}. Note=Predominantly in the mitochondria and in the nucleus. {ECO:0000255|HAMAP- Rule:MF_03152}.
|